Nozma
Generic Name
Desloratadine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nozma 10 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Desloratadine is a non-drowsy antihistamine used to relieve allergy symptoms such as sneezing, runny nose, itchy or watery eyes, and hives. It is a long-acting selective peripheral H1-receptor antagonist.
Uses & Indications
Dosage
Adults
Usually 5 mg orally once daily. For severe cases or specific conditions, 10 mg once daily may be prescribed by a physician.
Elderly
No specific dose adjustment is usually required for elderly patients with normal renal function. Use with caution in those with renal or hepatic impairment.
Renal_impairment
Dosage adjustment may be necessary. For severe renal impairment, consider 5 mg every other day.
How to Take
Take orally with or without food. Do not crush or chew the tablet; swallow whole.
Mechanism of Action
Desloratadine is a long-acting tricyclic antihistamine with selective peripheral H1-receptor antagonist activity. It inhibits histamine release from mast cells and basophils, and also inhibits a variety of pro-inflammatory mediators.
Pharmacokinetics
Onset
Within 30 minutes to 1 hour.
Excretion
Primarily excreted in urine and feces as metabolites.
Half life
Approximately 27 hours.
Absorption
Rapidly absorbed after oral administration. Food does not affect absorption.
Metabolism
Extensively metabolized to 3-hydroxydesloratadine, an active metabolite, via cytochrome P450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to desloratadine, loratadine, or any component of the formulation.
Drug Interactions
Cimetidine
Increased plasma concentration of desloratadine.
Fluoxetine
Increased plasma concentration of desloratadine.
Erythromycin
Increased plasma concentration of desloratadine.
Ketoconazole
Increased plasma concentration of desloratadine.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, somnolence, headache, tachycardia. Management is symptomatic and supportive. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Desloratadine is excreted into breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available (Off-patent)
Clinical Trials
Extensive clinical trials have demonstrated Desloratadine's efficacy and safety in treating allergic rhinitis and chronic idiopathic urticaria, with a favorable tolerability profile compared to first-generation antihistamines.
Lab Monitoring
- No routine lab monitoring is required. Liver function tests may be considered in patients with pre-existing hepatic impairment or during long-term use if clinically indicated.
Doctor Notes
- Emphasize non-sedating nature for patient compliance.
- Advise patients on proper administration and potential interactions.
- Monitor for unusual or severe adverse effects, especially in patients with pre-existing conditions.
Patient Guidelines
- Do not exceed the recommended dose.
- Inform your doctor if symptoms do not improve or worsen.
- Avoid alcohol while taking this medication as it may increase drowsiness.
- Take the tablet whole, do not chew or crush.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once.
Driving Precautions
Generally considered non-sedating, but individual response may vary. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Identify and avoid known allergens.
- Keep hydrated.
- Maintain a clean living environment to reduce exposure to allergens.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.