Nucef-CV
Generic Name
Cefixime + Clavulanic Acid
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nucef cv 250 mg tablet | ৳ 35.00 | ৳ 140.00 |
Description
Overview of the medicine
Nucef-CV 250 mg Tablet is a combination antibiotic used to treat a wide range of bacterial infections. It contains Cefixime, a third-generation cephalosporin, which fights bacteria by inhibiting cell wall synthesis, and Clavulanic Acid, a beta-lactamase inhibitor, which prevents bacterial enzymes from destroying Cefixime.
Uses & Indications
Dosage
Adults
The usual adult dose is Cefixime 200 mg + Clavulanic Acid 125 mg, orally twice daily. For Nucef-CV 250 mg Tablet, consult a physician for specific dosage, as it's an atypical strength for a combination with clavulanic acid. Typically, 250mg Cefixime would be combined with 62.5mg or 125mg Clavulanic Acid, taken twice daily.
Elderly
No specific dose adjustment is required in elderly patients with normal renal function. However, renal function should be monitored.
Renal_impairment
For patients with creatinine clearance <60 mL/min, dosage adjustment is necessary. For creatinine clearance between 20-40 mL/min, reduce dose by half or increase dosing interval. For <20 mL/min, further reduction is needed.
How to Take
Take the tablet orally with or without food, preferably at the same time each day, as directed by your doctor. Swallow the tablet whole with water; do not crush, chew, or break it.
Mechanism of Action
Cefixime binds to penicillin-binding proteins (PBPs) in the bacterial cell wall, inhibiting peptidoglycan synthesis, which leads to bacterial cell lysis and death. Clavulanic Acid, a beta-lactamase inhibitor, irreversibly binds to and inactivates beta-lactamase enzymes produced by bacteria, thus protecting Cefixime from degradation and extending its spectrum of activity.
Pharmacokinetics
Onset
Within 1-2 hours for Cefixime; Clavulanic acid peak plasma levels usually reached within 1 hour.
Excretion
Cefixime: Primarily excreted unchanged in urine via glomerular filtration and tubular secretion. Clavulanic Acid: Excreted renally as metabolites and unchanged drug.
Half life
Cefixime: 3-4 hours. Clavulanic Acid: Approximately 1 hour.
Absorption
Cefixime: Approximately 40-50% orally absorbed. Clavulanic Acid: Readily absorbed from the gastrointestinal tract.
Metabolism
Cefixime: Minimally metabolized. Clavulanic Acid: Extensively metabolized.
Side Effects
Contraindications
- Known hypersensitivity to cefixime, clavulanic acid, any other cephalosporin antibiotics, or penicillin antibiotics.
- History of severe hypersensitivity reactions to beta-lactam antibiotics.
Drug Interactions
Nifedipine
May increase cefixime plasma concentrations.
Probenecid
May increase cefixime plasma concentrations by decreasing renal tubular secretion.
Carbamazepine
Cefixime may increase carbamazepine levels.
Anticoagulants (e.g., Warfarin)
May increase the anticoagulant effect, leading to an increased risk of bleeding. Monitor INR closely.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be given. Gastric lavage may be indicated. Hemodialysis or peritoneal dialysis does not remove significant quantities of cefixime or clavulanic acid from the body.
Pregnancy & Lactation
Use in pregnancy and lactation should only be considered if the potential benefit outweighs the potential risk to the fetus or infant. Consult a doctor.
Side Effects
Contraindications
- Known hypersensitivity to cefixime, clavulanic acid, any other cephalosporin antibiotics, or penicillin antibiotics.
- History of severe hypersensitivity reactions to beta-lactam antibiotics.
Drug Interactions
Nifedipine
May increase cefixime plasma concentrations.
Probenecid
May increase cefixime plasma concentrations by decreasing renal tubular secretion.
Carbamazepine
Cefixime may increase carbamazepine levels.
Anticoagulants (e.g., Warfarin)
May increase the anticoagulant effect, leading to an increased risk of bleeding. Monitor INR closely.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be given. Gastric lavage may be indicated. Hemodialysis or peritoneal dialysis does not remove significant quantities of cefixime or clavulanic acid from the body.
Pregnancy & Lactation
Use in pregnancy and lactation should only be considered if the potential benefit outweighs the potential risk to the fetus or infant. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from the date of manufacture, specific to the packaging.
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Clinical trials have demonstrated the efficacy and safety of Cefixime and Clavulanic Acid combination in treating various bacterial infections. Ongoing research focuses on antibiotic resistance patterns and new formulations.
Lab Monitoring
- Complete Blood Count (CBC) with prolonged therapy
- Liver function tests (LFTs) periodically
- Renal function tests (e.g., creatinine, BUN) in patients with renal impairment
Doctor Notes
- Advise patients to report any signs of hypersensitivity reactions (e.g., rash, swelling) immediately.
- Emphasize the importance of completing the full course to minimize resistance.
- Monitor for severe diarrhea, which could indicate Clostridium difficile-associated diarrhea.
Patient Guidelines
- Complete the entire prescribed course of treatment, even if symptoms improve, to prevent the development of antibiotic resistance.
- Do not share this medicine with others, even if they have similar symptoms.
- Report any severe or persistent side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Nucef-CV is generally not expected to affect the ability to drive or operate machinery. However, if side effects like dizziness occur, patients should avoid such activities.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids during the treatment period.
- Avoid alcohol consumption as it may worsen some side effects.
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