Nurela
Generic Name
Pregabalin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nurela 50 mg capsule | ৳ 12.00 | N/A |
Description
Overview of the medicine
Nurela 50 mg Capsule contains Pregabalin, an anticonvulsant and analgesic medicine. It is primarily used to treat neuropathic pain, partial onset seizures in epilepsy, and generalized anxiety disorder.
Uses & Indications
Dosage
Adults
Initial dose is typically 50 mg three times daily (150 mg/day) or 75 mg twice daily (150 mg/day) for neuropathic pain or generalized anxiety disorder, and may be increased based on response and tolerability, up to a maximum of 600 mg/day. For epilepsy, it usually starts with 75 mg twice daily and titrated up.
Elderly
Dose adjustment may be necessary in elderly patients due to potential age-related decrease in renal function. Start with a lower dose.
Renal_impairment
Significant dose reduction is required for patients with impaired renal function based on creatinine clearance. For CrCl 30-60 mL/min, maximum 300 mg/day; for CrCl 15-30 mL/min, maximum 150 mg/day; for CrCl <15 mL/min, maximum 75 mg/day.
How to Take
Take orally with or without food. Swallow the capsule whole with water. Do not crush, chew, or open the capsule.
Mechanism of Action
Pregabalin binds with high affinity to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system, which reduces the release of several neurotransmitters, including glutamate, norepinephrine, and substance P. This action is believed to mediate its anticonvulsant, anxiolytic, and analgesic effects.
Pharmacokinetics
Onset
Variable, depending on condition, usually within 1 week for pain, longer for anxiety/epilepsy.
Excretion
Excreted predominantly unchanged in the urine (approximately 98% of the dose).
Half life
Approximately 6.3 hours.
Absorption
Rapidly absorbed following oral administration. Peak plasma concentrations are achieved within 1 to 1.5 hours. Bioavailability is ≥90% and is not affected by food.
Metabolism
Negligible, less than 0.1% metabolized.
Side Effects
Contraindications
- Known hypersensitivity to pregabalin or any component of the formulation
Drug Interactions
ACE inhibitors (e.g., captopril, enalapril)
May increase the risk of angioedema when co-administered with pregabalin.
CNS Depressants (e.g., opioids, benzodiazepines, alcohol)
May potentiate CNS depressant effects, leading to increased sedation, respiratory depression, and coma.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms include somnolence, confusion, agitation, and restlessness. Treatment is supportive and symptomatic, which may include gastric lavage and general supportive measures. Hemodialysis is an effective method for removing pregabalin from the plasma.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted in human milk; a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture, refer to package for exact expiry.
Availability
Available in pharmacies and hospitals
Approval Status
FDA approved
Patent Status
Generic versions available, original patent expired
Clinical Trials
Pregabalin has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of neuropathic pain, epilepsy, and generalized anxiety disorder. Studies have shown significant reductions in pain scores, seizure frequency, and anxiety symptoms compared to placebo.
Lab Monitoring
- Renal function (creatinine clearance) should be monitored, especially in elderly patients or those with pre-existing renal impairment. Monitor for signs of suicidal ideation or depression.
Doctor Notes
- Assess renal function before initiating therapy and adjust dose accordingly.
- Monitor patients for signs of suicidal ideation, especially during initial therapy or dose changes.
- Advise patients about potential for dizziness, somnolence, and blurred vision, and counsel on safe operation of vehicles or machinery.
- Educate patients on the importance of gradual tapering when discontinuing treatment.
Patient Guidelines
- Do not stop taking this medicine abruptly; doses should be tapered gradually over at least one week to avoid withdrawal symptoms.
- Report any changes in mood, behavior, or suicidal thoughts to your doctor immediately.
- Avoid alcohol consumption while taking pregabalin, as it may enhance CNS depressant effects.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Pregabalin may cause dizziness, somnolence, and blurred vision, which could impair your ability to drive or operate machinery. Patients should be advised not to drive, operate complex machinery, or engage in other hazardous activities until they have gained sufficient experience with Pregabalin to gauge whether it adversely affects their abilities.
Lifestyle Advice
- Maintain a healthy and balanced diet.
- Engage in regular, moderate exercise if possible.
- Practice stress-reducing techniques such as meditation or yoga.
- Avoid driving or operating heavy machinery until you know how this medicine affects you.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.