Nurobix Plus
Generic Name
Thiamine Mononitrate + Pyridoxine Hydrochloride + Cyanocobalamin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nurobix plus 100 mg tablet | ৳ 8.50 | N/A |
Description
Overview of the medicine
Nurobix Plus 100 mg Tablet is a combination of B vitamins (B1, B6, B12) used to treat or prevent vitamin deficiencies, especially those affecting nerve health.
Uses & Indications
Dosage
Adults
Usually 1 tablet daily, or as directed by the physician.
Elderly
Same as adult dose, but may require dose adjustment based on individual health status.
Renal_impairment
Generally safe, but caution advised in severe renal impairment. Consult physician.
How to Take
To be taken orally with water, preferably after meals.
Mechanism of Action
Thiamine (B1) is essential for carbohydrate metabolism and nerve function. Pyridoxine (B6) is involved in amino acid and neurotransmitter metabolism. Cyanocobalamin (B12) is crucial for DNA synthesis, myelin sheath formation, and red blood cell production.
Pharmacokinetics
Onset
Varies; symptomatic relief may be seen within days to weeks.
Excretion
Mainly renal excretion of inactive metabolites and excess unabsorbed vitamins.
Half life
Thiamine: 18-36 hours. Pyridoxine: 15-20 days (for phosphorylated forms). Cyanocobalamin: 6 days (plasma).
Absorption
Well absorbed orally, mainly from the small intestine. Thiamine and Pyridoxine are absorbed rapidly, while B12 absorption requires intrinsic factor.
Metabolism
Thiamine is metabolized in the liver. Pyridoxine is converted to active forms (e.g., pyridoxal phosphate) in the liver. Cyanocobalamin is metabolized in the liver and stored.
Side Effects
Contraindications
- Hypersensitivity to any of the ingredients.
- Leber's disease (due to cyanocobalamin).
Drug Interactions
Levodopa
Pyridoxine may reduce the efficacy of Levodopa in Parkinson's disease, unless combined with a decarboxylase inhibitor.
Phenobarbital, Phenytoin
Pyridoxine may decrease serum concentrations of phenobarbital and phenytoin.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture.
Overdose
Overdose is rare due to water-solubility. High doses of pyridoxine over long periods may cause sensory neuropathy. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Generally considered safe in recommended doses, but consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to any of the ingredients.
- Leber's disease (due to cyanocobalamin).
Drug Interactions
Levodopa
Pyridoxine may reduce the efficacy of Levodopa in Parkinson's disease, unless combined with a decarboxylase inhibitor.
Phenobarbital, Phenytoin
Pyridoxine may decrease serum concentrations of phenobarbital and phenytoin.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture.
Overdose
Overdose is rare due to water-solubility. High doses of pyridoxine over long periods may cause sensory neuropathy. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Generally considered safe in recommended doses, but consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Drugstores
Approval Status
Approved by DGDA
Patent Status
Generic
Clinical Trials
As a long-established vitamin combination, extensive clinical trials for this specific combination are not routinely performed. Efficacy is based on individual component studies.
Lab Monitoring
- No routine lab monitoring is required for typical therapeutic doses.
- Monitoring of B vitamin levels may be done in cases of suspected deficiency or malabsorption.
Doctor Notes
- Advise patients on the importance of adherence, especially for neuropathic symptoms.
- Emphasize that this is a supplement/adjuvant therapy and not a cure for underlying conditions.
Patient Guidelines
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Report any unusual symptoms.
Missed Dose Advice
Take the missed dose as soon as you remember. If it's near the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
Generally no known adverse effects on driving. If dizziness occurs, avoid driving.
Lifestyle Advice
- Maintain a balanced diet to ensure adequate vitamin intake.
- Avoid excessive alcohol consumption, as it can interfere with B vitamin absorption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.