Nx-Plus
Generic Name
Naproxen
Manufacturer
General Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nx plus 375 mg tablet | ৳ 12.50 | ৳ 125.00 |
Description
Overview of the medicine
Naproxen is a Non-Steroidal Anti-Inflammatory Drug (NSAID) used to relieve pain, inflammation, and fever.
Uses & Indications
Dosage
Adults
Typically 250-500 mg twice daily, or 375 mg twice daily for sustained release formulations, not exceeding 1250 mg daily.
Elderly
Lower doses may be required; monitor for adverse effects.
Renal_impairment
Reduced dosage or avoidance in severe renal impairment; monitor renal function closely.
How to Take
Oral. Should be taken with food or milk to minimize gastrointestinal upset.
Mechanism of Action
Inhibits prostaglandin synthesis by blocking cyclooxygenase (COX-1 and COX-2) enzymes.
Pharmacokinetics
Onset
Pain relief within 1 hour.
Excretion
Primarily excreted in the urine (about 95% as metabolites).
Half life
12-17 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal (GI) tract. Peak plasma levels usually within 2-4 hours.
Metabolism
Primarily metabolized in the liver by demethylation and glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to naproxen or other NSAIDs
- Asthma, urticaria, or allergic-type reactions after aspirin or other NSAIDs
- Active gastrointestinal bleeding or ulceration
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased lithium levels
Methotrexate
Increased methotrexate toxicity
Anticoagulants
Increased risk of bleeding
Corticosteroids
Increased risk of GI side effects
ACE Inhibitors/Diuretics
Reduced antihypertensive and diuretic effects, increased risk of renal impairment
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, heartburn, nausea, vomiting, epigastric pain, and GI bleeding. Management includes gastric lavage, activated charcoal, and supportive care.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of ductus arteriosus. Use with caution during first and second trimesters only if clearly needed. Excreted in breast milk, use with caution or consider alternatives.
Side Effects
Contraindications
- Hypersensitivity to naproxen or other NSAIDs
- Asthma, urticaria, or allergic-type reactions after aspirin or other NSAIDs
- Active gastrointestinal bleeding or ulceration
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
Drug Interactions
Lithium
Increased lithium levels
Methotrexate
Increased methotrexate toxicity
Anticoagulants
Increased risk of bleeding
Corticosteroids
Increased risk of GI side effects
ACE Inhibitors/Diuretics
Reduced antihypertensive and diuretic effects, increased risk of renal impairment
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, heartburn, nausea, vomiting, epigastric pain, and GI bleeding. Management includes gastric lavage, activated charcoal, and supportive care.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of ductus arteriosus. Use with caution during first and second trimesters only if clearly needed. Excreted in breast milk, use with caution or consider alternatives.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of naproxen for various inflammatory and pain conditions.
Lab Monitoring
- Complete blood count (CBC)
- Liver function tests (LFTs)
- Renal function tests (RFTs)
- Stool for occult blood
Doctor Notes
- Monitor patients with a history of GI issues or cardiovascular disease closely.
- Caution in elderly patients and those with renal or hepatic impairment.
- Educate patients on potential adverse effects and drug interactions.
Patient Guidelines
- Take with food or milk to minimize stomach upset.
- Do not exceed the prescribed dose.
- Inform your doctor about all other medications you are taking.
- Report any signs of unusual bleeding or stomach pain immediately.
Missed Dose Advice
Take the missed dose as soon as you remember. If it's near the time for your next dose, skip the missed dose and continue your regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness; use caution when driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption.
- Quit smoking to reduce GI risks.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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