Nytenso
Generic Name
Nytenartan
Manufacturer
Fictional Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nytenso 20 mg tablet | ৳ 35.00 | ৳ 350.00 |
Description
Overview of the medicine
Nytenso 20 mg tablet contains Nytenartan, an angiotensin II receptor blocker (ARB), used to treat high blood pressure (hypertension) and heart failure. It helps to relax blood vessels, allowing blood to flow more easily.
Uses & Indications
Dosage
Adults
The usual starting dose is 20 mg once daily. The dose may be increased to 40 mg once daily depending on the blood pressure response.
Elderly
No initial dosage adjustment is usually necessary, but lower starting doses may be considered for patients >75 years with significant renal impairment.
Renal_impairment
Initial dose of 10 mg once daily is recommended for patients with moderate to severe renal impairment. Careful monitoring is advised.
How to Take
Take Nytenso tablet orally with or without food, at the same time each day, preferably in the morning.
Mechanism of Action
Nytenartan selectively blocks the binding of angiotensin II to the AT1 receptor, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This leads to vasodilation, decreased blood pressure, and reduced fluid retention.
Pharmacokinetics
Onset
Onset of antihypertensive effect within 1-2 hours.
Excretion
Primarily excreted via bile and urine, with about 30% excreted unchanged in urine.
Half life
Elimination half-life is approximately 6-9 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract with an oral bioavailability of approximately 30-40%.
Metabolism
Undergoes extensive hepatic metabolism, with some active metabolites.
Side Effects
Contraindications
- Hypersensitivity to Nytenartan or any component of the formulation
- Pregnancy (especially in the second and third trimesters)
- Concomitant use with aliskiren in patients with diabetes or renal impairment
- History of angioedema related to previous ARB or ACE inhibitor therapy
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity have been reported with concomitant use of ARBs.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal function deterioration.
Potassium-sparing diuretics & Potassium supplements
May lead to increased serum potassium levels (hyperkalemia).
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension (low blood pressure) and tachycardia; bradycardia might occur. Management involves symptomatic and supportive treatment, including intravenous fluid administration.
Pregnancy & Lactation
Nytenso is contraindicated during pregnancy, especially in the second and third trimesters, due to risks of fetal injury and death. It is not recommended during lactation; evaluate the potential risks and benefits.
Side Effects
Contraindications
- Hypersensitivity to Nytenartan or any component of the formulation
- Pregnancy (especially in the second and third trimesters)
- Concomitant use with aliskiren in patients with diabetes or renal impairment
- History of angioedema related to previous ARB or ACE inhibitor therapy
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity have been reported with concomitant use of ARBs.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal function deterioration.
Potassium-sparing diuretics & Potassium supplements
May lead to increased serum potassium levels (hyperkalemia).
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension (low blood pressure) and tachycardia; bradycardia might occur. Management involves symptomatic and supportive treatment, including intravenous fluid administration.
Pregnancy & Lactation
Nytenso is contraindicated during pregnancy, especially in the second and third trimesters, due to risks of fetal injury and death. It is not recommended during lactation; evaluate the potential risks and benefits.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies nationwide in Bangladesh
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Nytenartan in reducing blood pressure and improving outcomes in patients with hypertension and heart failure. Studies have shown comparable efficacy to other ARBs with a favorable safety profile.
Lab Monitoring
- Serum potassium levels
- Renal function (serum creatinine, BUN, GFR)
- Liver function tests (baseline and if symptoms occur)
Doctor Notes
- Advise patients about potential dizziness, especially with the first dose or dose escalation.
- Monitor serum potassium and renal function periodically, particularly in patients with pre-existing renal impairment or those on potassium-sparing diuretics.
- Counsel female patients of childbearing potential about the risks of fetal harm if Nytenso is used during pregnancy.
Patient Guidelines
- Take the medicine regularly as prescribed, even if you feel well.
- Do not stop taking Nytenso without consulting your doctor.
- Monitor your blood pressure at home if advised by your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Nytenso may cause dizziness or lightheadedness, especially at the start of treatment. Use caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain a healthy diet low in sodium and saturated fats.
- Engage in regular physical activity.
- Avoid smoking and limit alcohol consumption.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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