Take Obemet 500 mg Tablet orally with meals to reduce gastrointestinal side effects. Swallow the tablet whole; do not crush or chew.

Metformin works by decreasing glucose production by the liver, decreasing intestinal absorption of glucose, and improving insulin sensitivity by increasing peripheral glucose uptake and utilization. It does not stimulate insulin secretion and therefore does not cause hypoglycemia in non-diabetic individuals.

• •Severe renal impairment (eGFR < 30 mL/min/1.73 m²)
• •Metabolic acidosis, including diabetic ketoacidosis
• •Hypersensitivity to metformin hydrochloride
• •Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma
• •Hepatic impairment, acute myocardial infarction, severe heart failure, alcoholism

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose of metformin may lead to lactic acidosis, which is a medical emergency. Symptoms include malaise, myalgias, respiratory distress, somnolence, and abdominal pain. Management involves hemodialysis to remove metformin and correct acidosis.

Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Insulin is generally preferred for managing diabetes during pregnancy. Small amounts of metformin are excreted in breast milk; consult a doctor before breastfeeding.