Ocarnix
Generic Name
ocarnix-500-mg-oral-solution
Manufacturer
PharmaGen Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ocarnix 500 mg oral solution | ৳ 100.00 | N/A |
Description
Overview of the medicine
Ocarnix 500 mg Oral Solution is a broad-spectrum macrolide antibiotic used to treat various bacterial infections, including respiratory tract infections, skin and soft tissue infections, and genitourinary infections. It works by inhibiting bacterial protein synthesis.
Uses & Indications
Dosage
Adults
Typically 500 mg once daily for 3-7 days, depending on the infection type and severity.
Elderly
No specific dose adjustment is generally required in elderly patients, but monitoring of renal and hepatic function is advised.
Renal_impairment
No dose adjustment needed for mild to moderate renal impairment. Use with caution in severe renal impairment (CrCl < 10 mL/min).
How to Take
Ocarnix oral solution can be taken with or without food. Administer the full prescribed dose using the provided measuring device. Shake well before use.
Mechanism of Action
Ocarnix acts by binding to the 50S ribosomal subunit of susceptible bacteria, thereby inhibiting protein synthesis and consequently bacterial growth and replication. It is primarily bacteriostatic.
Pharmacokinetics
Onset
Onset of antibacterial activity typically within 1-2 hours of administration.
Excretion
Mainly excreted unchanged through biliary excretion; a minor portion is renally excreted.
Half life
Elimination half-life ranges from 12 to 18 hours, allowing for once-daily dosing.
Absorption
Rapidly absorbed from the gastrointestinal tract; oral bioavailability is good and not significantly affected by food.
Metabolism
Primarily metabolized in the liver via cytochrome P450 enzymes (particularly CYP3A4).
Side Effects
Contraindications
- Known hypersensitivity to ocarnix, other macrolide antibiotics, or any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior macrolide use.
- Severe hepatic impairment.
Drug Interactions
Digoxin
May increase serum digoxin levels; monitor digoxin levels and adjust dose if necessary.
Warfarin
Increased anticoagulant effect (elevated INR) has been reported; monitor INR closely.
Nelfinavir
Concomitant use may increase Ocarnix serum concentrations.
Antacids (containing aluminum or magnesium)
May reduce the absorption of Ocarnix if taken concurrently. Administer Ocarnix at least 2 hours before or 4 hours after antacids.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Do not freeze. Keep out of sight and reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves gastric lavage, supportive care, and monitoring of vital signs. Hemodialysis is not effective in removing Ocarnix.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use Ocarnix during pregnancy only if clearly needed. Ocarnix is excreted in breast milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Known hypersensitivity to ocarnix, other macrolide antibiotics, or any component of the formulation.
- History of cholestatic jaundice/hepatic dysfunction associated with prior macrolide use.
- Severe hepatic impairment.
Drug Interactions
Digoxin
May increase serum digoxin levels; monitor digoxin levels and adjust dose if necessary.
Warfarin
Increased anticoagulant effect (elevated INR) has been reported; monitor INR closely.
Nelfinavir
Concomitant use may increase Ocarnix serum concentrations.
Antacids (containing aluminum or magnesium)
May reduce the absorption of Ocarnix if taken concurrently. Administer Ocarnix at least 2 hours before or 4 hours after antacids.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Do not freeze. Keep out of sight and reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves gastric lavage, supportive care, and monitoring of vital signs. Hemodialysis is not effective in removing Ocarnix.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use Ocarnix during pregnancy only if clearly needed. Ocarnix is excreted in breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months when unopened, stored as recommended. Once reconstituted or opened, refer to specific product instructions for stability.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies
Patent Status
Patent expired; Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated Ocarnix's efficacy and safety in treating various bacterial infections. Studies showed high eradication rates for susceptible pathogens and a favorable safety profile compared to other macrolides.
Lab Monitoring
- Liver function tests (ALT, AST, ALP, bilirubin) should be monitored in patients receiving prolonged therapy or with pre-existing hepatic impairment.
- International Normalized Ratio (INR) should be monitored frequently in patients receiving concomitant warfarin.
Doctor Notes
- Emphasize the importance of completing the full course to patients, even if they feel better, to prevent resistance.
- Counsel patients on potential drug interactions, especially with warfarin and antacids.
- Advise on recognition and reporting of severe adverse effects like allergic reactions or severe diarrhea.
Patient Guidelines
- Complete the entire course of therapy, even if symptoms improve, to prevent resistance and recurrence.
- Do not share your medication with others.
- Report any unusual or severe side effects to your doctor immediately.
- Store the medicine as directed and keep out of reach of children.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Ocarnix may cause dizziness or visual disturbances in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how Ocarnix affects them.
Lifestyle Advice
- Maintain adequate hydration, especially if experiencing diarrhea.
- Avoid alcohol consumption during treatment if advised by your doctor, as it may exacerbate side effects.
- Practice good hygiene to prevent the spread of infection.
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