Ocusol
Generic Name
ocusol-1-suspension
Manufacturer
Bausch + Lomb (historical)
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ocusol 1 suspension | ৳ 100.00 | N/A |
Description
Overview of the medicine
Ocusol-1-Suspension is an ophthalmic antibiotic suspension containing Sulfacetamide Sodium, used for the treatment of various bacterial eye infections.
Uses & Indications
Dosage
Adults
Instill 1-2 drops into the affected eye(s) every 2-4 hours initially, then gradually reduce frequency as infection responds. Continue for 7-10 days.
Elderly
No specific dosage adjustment needed for elderly patients.
Renal_impairment
No specific dosage adjustment needed due to minimal systemic absorption.
How to Take
For ophthalmic use only. Shake well before use. Do not touch the dropper tip to any surface to avoid contamination.
Mechanism of Action
Sulfacetamide Sodium inhibits bacterial dihydrofolic acid synthesis by competing with para-aminobenzoic acid (PABA), thereby preventing bacterial growth. It acts as a bacteriostatic agent against a wide range of gram-positive and gram-negative bacteria.
Pharmacokinetics
Onset
Within hours of administration.
Excretion
Systemically absorbed portion excreted renally; majority remains at local site or is washed out.
Half life
Not precisely determined for topical ophthalmic use, but local effects persist for several hours.
Absorption
Minimal systemic absorption after topical ocular administration. High concentrations achieved in ocular fluids and tissues.
Metabolism
Primarily hepatic metabolism for systemically absorbed sulfonamides; minimal systemic absorption means minimal hepatic metabolism from ophthalmic use.
Side Effects
Contraindications
- Hypersensitivity to sulfacetamide or any component of the formulation.
- Patients with a history of Stevens-Johnson syndrome.
- Neonates (due to risk of kernicterus).
Drug Interactions
Silver preparations
Concurrent use with silver preparations (e.g., silver nitrate) may lead to precipitation and inactivation of sulfacetamide.
PABA-containing anesthetics
Local anesthetics containing para-aminobenzoic acid (PABA) (e.g., procaine, tetracaine) may inhibit the action of sulfacetamide.
Storage
Store at controlled room temperature (15-30°C), protect from light. Do not freeze.
Overdose
Overdose is unlikely with topical ophthalmic use. If accidental ingestion occurs, treat symptomatically and provide supportive care.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Caution in breastfeeding mothers as sulfacetamide can be excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to sulfacetamide or any component of the formulation.
- Patients with a history of Stevens-Johnson syndrome.
- Neonates (due to risk of kernicterus).
Drug Interactions
Silver preparations
Concurrent use with silver preparations (e.g., silver nitrate) may lead to precipitation and inactivation of sulfacetamide.
PABA-containing anesthetics
Local anesthetics containing para-aminobenzoic acid (PABA) (e.g., procaine, tetracaine) may inhibit the action of sulfacetamide.
Storage
Store at controlled room temperature (15-30°C), protect from light. Do not freeze.
Overdose
Overdose is unlikely with topical ophthalmic use. If accidental ingestion occurs, treat symptomatically and provide supportive care.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Caution in breastfeeding mothers as sulfacetamide can be excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 months, check product label for exact expiry date. Discard 28 days after opening.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA/DGDA)
Patent Status
Expired
Clinical Trials
Sulfacetamide has been extensively studied and used clinically for decades. Modern clinical trials typically focus on new formulations or comparative efficacy.
Lab Monitoring
- No routine lab monitoring is required for topical ophthalmic use.
Doctor Notes
- Advise patients about potential for yellowing of contact lenses or other soft lenses if worn during treatment.
- Ensure proper instillation technique to maximize efficacy and minimize contamination.
Patient Guidelines
- Complete the full course of treatment even if symptoms improve.
- Avoid wearing contact lenses during treatment.
- Wash hands before and after applying the drops.
Missed Dose Advice
If a dose is missed, apply it as soon as remembered. If it is close to the time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause transient blurred vision; patients should wait until vision clears before driving or operating machinery.
Lifestyle Advice
- Maintain good eye hygiene.
- Avoid rubbing eyes.
- Use fresh towels and pillowcases.
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