Ocutob
Generic Name
Tobramycin
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ocutob 03 eye drop | ৳ 85.00 | N/A |
Description
Overview of the medicine
Ocutob-03 Eye Drop contains Tobramycin, an aminoglycoside antibiotic, used for the topical treatment of external bacterial infections of the eye and its adnexa.
Uses & Indications
Dosage
Adults
For mild to moderate infections, one or two drops into the affected eye(s) every 4 hours. For severe infections, two drops into the affected eye(s) hourly until improvement, then reduce frequency.
Elderly
No specific dose adjustment required for elderly patients.
Renal_impairment
No specific dose adjustment required for topical ophthalmic use.
How to Take
For topical ocular use only. Tilt head back, pull down lower eyelid to form a pocket, instil drops, close eye gently, and apply pressure to the corner of the eye near the nose for a minute to reduce systemic absorption.
Mechanism of Action
Tobramycin exerts its bactericidal effect by inhibiting bacterial protein synthesis through binding to the 30S ribosomal subunit.
Pharmacokinetics
Onset
Clinical improvement often seen within 1-2 days.
Excretion
Primarily renal excretion (if systemically absorbed).
Half life
Not well-defined for ophthalmic topical use due to minimal systemic absorption; systemic half-life for IV tobramycin is 2-3 hours.
Absorption
Systemic absorption is minimal following topical ocular administration.
Metabolism
Not extensively metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to Tobramycin or any component of the formulation.
- Hypersensitivity to other aminoglycosides.
Drug Interactions
Other ophthalmic preparations
If using more than one ophthalmic product, administer them at least 5 minutes apart.
Storage
Store at room temperature (below 30°C). Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Topical ocular overdose is unlikely to produce systemic toxicity due to minimal absorption. Rinse eye with lukewarm water if excessive drops are applied.
Pregnancy & Lactation
Pregnancy Category B. Animal reproduction studies have not demonstrated a fetal risk but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Excretion into breast milk is unknown, use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years unopened; 28 days after opening.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of tobramycin ophthalmic solutions for bacterial eye infections.
Lab Monitoring
- Not typically required for topical ophthalmic use.
Doctor Notes
- Confirm bacterial infection before prescribing.
- Advise patients on proper instillation technique to avoid contamination.
- Monitor for signs of superinfection with prolonged use.
Patient Guidelines
- Wash hands thoroughly before and after applying eye drops.
- Do not touch the dropper tip to any surface (including the eye) to avoid contamination.
- Remove contact lenses before application and wait at least 15 minutes before reinserting.
Missed Dose Advice
If a dose is missed, apply it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause temporary blurred vision or other visual disturbances which could affect the ability to drive or operate machinery. If blurred vision occurs, wait until vision clears before driving or operating machinery.
Lifestyle Advice
- Avoid rubbing eyes.
- Complete the full course of treatment as prescribed, even if symptoms improve.
- Avoid sharing eye drops.
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Global Brand Names
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