Odatrix
Generic Name
Meropenem 500 mg Injection
Manufacturer
Pharmatech Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| odatrix 500 mg injection | ৳ 120.00 | N/A |
Description
Overview of the medicine
Odatrix 500 mg Injection contains Meropenem, a carbapenem antibiotic used to treat a wide range of severe bacterial infections in adults and children.
Uses & Indications
Dosage
Adults
Typically 500 mg to 1 g intravenously every 8 hours, depending on the severity and type of infection. Infusion over 15-30 minutes.
Elderly
No specific dose adjustment is needed based on age alone, but renal function should be assessed and dose adjusted if renal impairment is present.
Renal_impairment
Dose reduction is required for patients with creatinine clearance less than 50 mL/min. For CrCl 26-50 mL/min: 500 mg every 12 hours; For CrCl 10-25 mL/min: 250 mg every 12 hours.
How to Take
Administer intravenously as an infusion over 15-30 minutes, or as an intravenous bolus injection over 3-5 minutes (for doses up to 1 g).
Mechanism of Action
Meropenem inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Within minutes after intravenous administration.
Excretion
Excreted primarily unchanged by the kidneys (approximately 70% as unchanged drug within 12 hours).
Half life
Approximately 1 hour in adults with normal renal function.
Absorption
Rapidly and completely absorbed after intravenous administration, achieving peak plasma concentrations within 1 hour.
Metabolism
Limited hepatic metabolism; primarily hydrolyzed to an inactive metabolite.
Side Effects
Contraindications
- Hypersensitivity to Meropenem or any other carbapenem antibiotics.
- History of severe hypersensitivity (e.g., anaphylactic reaction, severe skin reaction) to any other beta-lactam antibacterial agent (e.g., penicillins or cephalosporins).
Drug Interactions
Probenecid
Concomitant administration of probenecid with meropenem inhibits the renal excretion of meropenem, resulting in increased plasma concentrations and prolonged half-life of meropenem. Co-administration is not recommended.
Valproic Acid
Reduced serum valproic acid levels, potentially leading to sub-therapeutic levels and loss of seizure control. Monitor valproic acid levels closely; consider alternative anticonvulsant therapy.
Oral Anticoagulants (e.g., Warfarin)
Increased anticoagulant effect, requiring close monitoring of INR.
Storage
Store below 30°C in a dry place, protected from light. Do not freeze. Keep out of reach of children.
Overdose
In case of overdose, discontinue Meropenem and initiate supportive treatment. Meropenem can be removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Meropenem is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months when stored as specified. Reconstituted solution must be used immediately or within a few hours if refrigerated.
Availability
Available in hospitals and pharmacies nationwide
Approval Status
Approved by Regulatory Authorities
Patent Status
Generic available, patent expired for active ingredient
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated Meropenem's efficacy and safety in various severe bacterial infections across different patient populations.
Lab Monitoring
- Renal function tests (creatinine, BUN) regularly, especially in patients with pre-existing renal impairment.
- Liver function tests (ALT, AST) if treatment is prolonged.
- Complete blood count (CBC) during prolonged therapy.
- Valproic acid levels if co-administered.
Doctor Notes
- Broad-spectrum carbapenem for serious Gram-positive and Gram-negative infections.
- Monitor renal function, especially in elderly or renally impaired patients; adjust dose accordingly.
- Beware of potential CNS side effects, including seizures, particularly in patients with pre-existing CNS disorders or compromised renal function.
- Consider drug interactions with probenecid and valproic acid.
Patient Guidelines
- Inform your doctor about all your medical conditions and medications.
- Do not stop treatment early, even if you feel better.
- Report any severe or persistent side effects to your healthcare provider.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness or seizures, which could impair the ability to drive or operate machinery. Patients should be advised to be cautious.
Lifestyle Advice
- Maintain good hydration throughout the treatment period.
- Avoid alcohol during treatment as it may exacerbate some side effects, though direct interactions with meropenem are not well-established.
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