Odofex
Generic Name
Fexofenadine Hydrochloride
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| odofex 120 mg tablet | ৳ 8.00 | N/A |
Description
Overview of the medicine
Odofex 120 mg Tablet contains Fexofenadine Hydrochloride, a second-generation antihistamine used to relieve allergy symptoms such as runny nose, sneezing, itchy eyes, and hives. It causes less drowsiness compared to first-generation antihistamines.
Uses & Indications
Dosage
Adults
For Seasonal Allergic Rhinitis: 120 mg once daily orally. For Chronic Idiopathic Urticaria: Consult physician for appropriate dosage, typically 180 mg once daily, but 120 mg may be used depending on severity and physician's discretion.
Elderly
No specific dosage adjustment is recommended for elderly patients with normal renal function.
Renal_impairment
For patients with impaired renal function (creatinine clearance ≤ 80 mL/min), an initial dose of 60 mg once daily is recommended. For 120 mg, dosage reduction or careful monitoring is advised.
How to Take
Take the tablet orally with water, preferably before a meal. Do not take with fruit juice as it may reduce absorption. Do not exceed the recommended dose.
Mechanism of Action
Fexofenadine is a selective peripheral H1-receptor antagonist. It competitively inhibits histamine at H1-receptors, preventing the histamine-induced effects such as vasodilation, increased vascular permeability, itching, and bronchoconstriction. It has minimal sedative effects due to its low penetration into the central nervous system.
Pharmacokinetics
Onset
1 hour
Excretion
Primarily excreted unchanged in bile (approx. 80%) and urine (approx. 10%).
Half life
Approximately 14-16 hours
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in approximately 1-3 hours. Food decreases the absorption slightly but is not clinically significant.
Metabolism
Minimally metabolized; about 5% of the dose undergoes hepatic metabolism.
Side Effects
Contraindications
- Hypersensitivity to Fexofenadine or any excipients
- Children under 6 years of age (for 120/180mg tablets)
Drug Interactions
Erythromycin
Increases fexofenadine plasma levels, but no significant increase in adverse events.
Ketoconazole
Increases fexofenadine plasma levels, but no significant increase in adverse events.
Antacids containing Aluminum and Magnesium
Reduce fexofenadine absorption. Separate administration by at least 2 hours.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, dizziness, and dry mouth. Management involves general symptomatic and supportive measures. Hemodialysis does not effectively remove fexofenadine from blood.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. It is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Fexofenadine or any excipients
- Children under 6 years of age (for 120/180mg tablets)
Drug Interactions
Erythromycin
Increases fexofenadine plasma levels, but no significant increase in adverse events.
Ketoconazole
Increases fexofenadine plasma levels, but no significant increase in adverse events.
Antacids containing Aluminum and Magnesium
Reduce fexofenadine absorption. Separate administration by at least 2 hours.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, dizziness, and dry mouth. Management involves general symptomatic and supportive measures. Hemodialysis does not effectively remove fexofenadine from blood.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies the potential risk to the fetus. It is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture.
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available (patent expired)
Clinical Trials
Extensive clinical trials have demonstrated fexofenadine's efficacy and safety in treating seasonal allergic rhinitis and chronic idiopathic urticaria, showing it to be well-tolerated with minimal sedative effects.
Lab Monitoring
- No routine lab monitoring is generally required.
Doctor Notes
- Advise patients to avoid taking with fruit juices.
- Patients with renal impairment may require dosage adjustment.
- Reassure patients about its non-sedating profile compared to older antihistamines.
Patient Guidelines
- Do not exceed the recommended dose.
- Avoid taking with fruit juices.
- Inform your doctor if symptoms do not improve or worsen.
- Avoid driving or operating machinery if you experience drowsiness.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Although Odofex is generally non-sedating, individual responses vary. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Identify and avoid known allergens.
- Keep windows closed during high pollen seasons.
- Maintain a clean indoor environment to minimize dust mites.
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