Ofex
Generic Name
Ofloxacin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ofex 200 mg capsule | ৳ 35.00 | ৳ 210.00 |
Description
Overview of the medicine
Ofex 200 mg Capsule contains Ofloxacin, a broad-spectrum fluoroquinolone antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
Usually 200 mg every 12 hours (twice daily) for 7-14 days, depending on the infection. For complicated UTIs, up to 400 mg twice daily. For uncomplicated gonorrhea, a single 400 mg dose.
Elderly
No specific dosage adjustment is required based solely on age, but renal function should be assessed and dose adjusted if impairment is present.
Renal_impairment
Dose adjustment is necessary. For CrCl 20-50 mL/min, 200 mg every 24 hours. For CrCl < 20 mL/min (including hemodialysis/CAPD), 100 mg every 24 hours.
How to Take
Take the capsule orally with a glass of water, with or without food. Do not chew or crush the capsule. It is important to complete the full course of treatment as prescribed by your doctor.
Mechanism of Action
Ofloxacin acts by inhibiting bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in bacterial DNA replication, transcription, repair, and recombination. This leads to bacterial cell death.
Pharmacokinetics
Onset
Plasma concentrations peak within 1-2 hours after oral administration.
Excretion
Primarily excreted unchanged in urine (70-80% within 24-48 hours), with minor fecal excretion.
Half life
Elimination half-life is typically 5-8 hours in patients with normal renal function.
Absorption
Rapid and well-absorbed orally, with bioavailability of approximately 98%.
Metabolism
Minimally metabolized; less than 10% is metabolized to desmethyl and N-oxide metabolites.
Side Effects
Contraindications
- Hypersensitivity to Ofloxacin or other fluoroquinolones
- History of tendon disorders related to quinolone administration
- Epilepsy or other seizure disorders
- Children and adolescents (due to risk of cartilage damage, generally avoided)
Drug Interactions
Warfarin
May enhance anticoagulant effects, requiring INR monitoring.
Theophylline
Increased plasma levels of Theophylline, potentially leading to toxicity.
Corticosteroids
Increased risk of tendon rupture.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of CNS stimulation and convulsive seizures.
Antacids (containing aluminum, magnesium), sucralfate, iron, zinc supplements
Reduce oral absorption of Ofloxacin. Administer Ofloxacin 2 hours before or 2 hours after these agents.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptoms may include nausea, vomiting, abdominal pain, dizziness, confusion, seizures, and increased QT interval. Management includes emptying the stomach by induced vomiting or gastric lavage, followed by supportive care and symptomatic treatment. Adequate hydration should be maintained. Hemodialysis or peritoneal dialysis may not be effective in removing Ofloxacin.
Pregnancy & Lactation
Pregnancy Category C. Ofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to Ofloxacin or other fluoroquinolones
- History of tendon disorders related to quinolone administration
- Epilepsy or other seizure disorders
- Children and adolescents (due to risk of cartilage damage, generally avoided)
Drug Interactions
Warfarin
May enhance anticoagulant effects, requiring INR monitoring.
Theophylline
Increased plasma levels of Theophylline, potentially leading to toxicity.
Corticosteroids
Increased risk of tendon rupture.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Increased risk of CNS stimulation and convulsive seizures.
Antacids (containing aluminum, magnesium), sucralfate, iron, zinc supplements
Reduce oral absorption of Ofloxacin. Administer Ofloxacin 2 hours before or 2 hours after these agents.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptoms may include nausea, vomiting, abdominal pain, dizziness, confusion, seizures, and increased QT interval. Management includes emptying the stomach by induced vomiting or gastric lavage, followed by supportive care and symptomatic treatment. Adequate hydration should be maintained. Hemodialysis or peritoneal dialysis may not be effective in removing Ofloxacin.
Pregnancy & Lactation
Pregnancy Category C. Ofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture when stored under recommended conditions.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Ofloxacin has undergone extensive clinical trials demonstrating its efficacy and safety across a broad range of bacterial infections. Ongoing research may explore new indications or formulations.
Lab Monitoring
- Renal function tests (e.g., serum creatinine, BUN) particularly in elderly or patients with pre-existing renal impairment.
- Complete blood count (CBC) during prolonged therapy.
- Liver function tests (LFTs) if hepatotoxicity is suspected or for prolonged use.
- INR monitoring for patients on concomitant warfarin therapy.
Doctor Notes
- Counsel patients on potential serious side effects, especially tendonitis/tendon rupture and peripheral neuropathy; instruct them to discontinue the drug and contact a healthcare professional immediately if these occur.
- Advise patients about potential CNS effects and photosensitivity.
- Ensure appropriate dose adjustment in patients with renal impairment.
- Consider drug interactions, particularly with antacids, warfarin, and NSAIDs.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor and complete the full course of treatment, even if you start feeling better.
- Do not skip doses or stop taking the medicine early, as this can lead to antibiotic resistance.
- Report any unusual pain, swelling, or bruising around joints (especially ankles, wrists, shoulders) immediately to your doctor.
- Avoid excessive exposure to sunlight or artificial UV light, as Ofloxacin can cause photosensitivity.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Ofloxacin may cause dizziness, lightheadedness, or visual disturbances. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain adequate hydration by drinking plenty of fluids while taking this medication.
- Avoid alcohol consumption as it may worsen some side effects like dizziness.
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