OFLOXACIN-POS
Generic Name
Ofloxacin 0.3% Eye Drop
Manufacturer
URSAPHARM Arzneimittel GmbH
Country
Germany
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ofloxacin pos 03 eye drop | ৳ 1,170.00 | N/A |
Description
Overview of the medicine
Ofloxacin 0.3% Eye Drop is a fluoroquinolone antibiotic used to treat bacterial infections of the eye, such as conjunctivitis and keratitis.
Uses & Indications
Dosage
Adults
For bacterial conjunctivitis: Instill 1-2 drops into the affected eye(s) every 2 to 4 hours for the first two days, then 1-2 drops four times daily. For bacterial keratitis/corneal ulcer: Instill 1-2 drops into the affected eye(s) every 30 minutes for the first two days, then 1-2 drops hourly for the next five to seven days, and then 1-2 drops four times daily until clinical cure.
Elderly
No specific dosage adjustment is required for elderly patients.
Renal_impairment
Not applicable for ophthalmic use due to minimal systemic absorption.
How to Take
For ophthalmic use only. Tilt your head back, pull down your lower eyelid to form a pouch, and instill the prescribed number of drops. Avoid touching the dropper tip to your eye or any other surface to prevent contamination. Close your eye gently for 1-2 minutes.
Mechanism of Action
Ofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Rapid onset of action, typically within minutes of instillation.
Excretion
Systemically absorbed portion is primarily excreted renally (via urine).
Half life
Systemic half-life is approximately 4-6 hours, but local half-life in ocular tissues varies.
Absorption
Limited systemic absorption following ophthalmic administration, with peak plasma concentrations generally below detectable levels.
Metabolism
Minimal systemic metabolism occurs.
Side Effects
Contraindications
- Hypersensitivity to ofloxacin, other quinolones, or any component of the formulation.
Drug Interactions
Topical Ophthalmic Medications
Concurrent use with other topical ophthalmic medications may require proper spacing (e.g., 5-10 minutes between applications) to avoid washout.
Storage
Store below 25°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Overdose is unlikely with ophthalmic administration. If accidentally swallowed, supportive care should be administered.
Pregnancy & Lactation
Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution is advised when administered to a nursing mother due to unknown systemic absorption into breast milk. Consult your doctor.
Side Effects
Contraindications
- Hypersensitivity to ofloxacin, other quinolones, or any component of the formulation.
Drug Interactions
Topical Ophthalmic Medications
Concurrent use with other topical ophthalmic medications may require proper spacing (e.g., 5-10 minutes between applications) to avoid washout.
Storage
Store below 25°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Overdose is unlikely with ophthalmic administration. If accidentally swallowed, supportive care should be administered.
Pregnancy & Lactation
Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution is advised when administered to a nursing mother due to unknown systemic absorption into breast milk. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Unopened: 2-3 years; After opening: Discard 28 days after first opening.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have demonstrated the efficacy and safety of ophthalmic ofloxacin in treating various bacterial ocular infections, showing high cure rates and good tolerability.
Lab Monitoring
- No specific laboratory monitoring is generally required for ophthalmic ofloxacin.
Doctor Notes
- Advise patients on proper instillation technique to maximize efficacy and minimize contamination.
- Instruct patients not to share eye drops.
- Monitor for signs of fungal superinfection if prolonged use is necessary.
Patient Guidelines
- Complete the full course of treatment as prescribed by your doctor, even if symptoms improve.
- Do not wear contact lenses during the treatment period.
- Avoid sharing eye drops with others to prevent contamination.
- Wash your hands before and after applying eye drops.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause temporary blurred vision or other visual disturbances. If you experience such effects, avoid driving or operating machinery until your vision clears.
Lifestyle Advice
- Maintain good eye hygiene.
- Avoid rubbing your eyes.
- Protect your eyes from dust and dirt.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.