Ogli
Generic Name
Oglitriptin
Manufacturer
Generic Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ogli 15 mg tablet | ৳ 8.03 | N/A |
Description
Overview of the medicine
Ogli 15 mg tablet contains Oglitriptin, a medication used to treat type 2 diabetes mellitus by improving blood sugar control. It works by increasing levels of natural substances called incretins.
Uses & Indications
Dosage
Adults
The recommended dose of Ogli 15 mg is one tablet (15 mg) orally once daily, with or without food.
Elderly
No dosage adjustment is required based on age alone. However, renal function should be assessed as elderly patients are more likely to have decreased renal function.
Renal_impairment
Dosage adjustment may be necessary for patients with moderate to severe renal impairment (eGFR < 45 mL/min/1.73m²). Consult prescribing information for specific recommendations.
How to Take
Take Ogli 15 mg tablet orally once daily, with or without food. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet.
Mechanism of Action
Oglitriptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by inhibiting the enzyme DPP-4, which is responsible for the inactivation of incretin hormones like Glucagon-Like Peptide-1 (GLP-1) and Glucose-dependent Insulinotropic Polypeptide (GIP). By preserving active incretins, Oglitriptin enhances glucose-dependent insulin secretion from pancreatic beta cells and reduces glucagon secretion from pancreatic alpha cells, thereby lowering blood glucose levels.
Pharmacokinetics
Onset
Blood glucose lowering effects typically observed within hours of administration.
Excretion
Primarily excreted renally (kidneys), with some hepatic (liver) excretion.
Half life
Approximately 12-24 hours, allowing for once-daily dosing.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations reached within 1-4 hours. Bioavailability is generally high (e.g., >80%).
Metabolism
Minimally metabolized; primarily excreted unchanged or via minor CYP3A4 pathways.
Side Effects
Contraindications
- History of serious hypersensitivity reactions (e.g., anaphylaxis, angioedema) to Oglitriptin or any excipients in the formulation.
- Type 1 diabetes mellitus.
- Diabetic ketoacidosis.
Drug Interactions
Strong CYP3A4 inducers
May decrease Oglitriptin exposure. Clinical significance often limited.
Strong CYP3A4 inhibitors
May increase Oglitriptin exposure. Dosage adjustment may be needed.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, discontinue Ogli 15 mg and initiate appropriate supportive treatment. Oglitriptin is unlikely to be removed by hemodialysis or peritoneal dialysis effectively.
Pregnancy & Lactation
Pregnancy Category B/C (Animal studies may show risk, but human data are insufficient. Use only if clearly needed). It is not known whether Oglitriptin is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- History of serious hypersensitivity reactions (e.g., anaphylaxis, angioedema) to Oglitriptin or any excipients in the formulation.
- Type 1 diabetes mellitus.
- Diabetic ketoacidosis.
Drug Interactions
Strong CYP3A4 inducers
May decrease Oglitriptin exposure. Clinical significance often limited.
Strong CYP3A4 inhibitors
May increase Oglitriptin exposure. Dosage adjustment may be needed.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In the event of an overdose, discontinue Ogli 15 mg and initiate appropriate supportive treatment. Oglitriptin is unlikely to be removed by hemodialysis or peritoneal dialysis effectively.
Pregnancy & Lactation
Pregnancy Category B/C (Animal studies may show risk, but human data are insufficient. Use only if clearly needed). It is not known whether Oglitriptin is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Patented
Clinical Trials
Clinical trials have shown that Oglitriptin 15 mg significantly improves glycemic control in patients with type 2 diabetes mellitus, both as monotherapy and in combination with other antidiabetic agents, with a favorable safety profile.
Lab Monitoring
- HbA1c levels (every 3-6 months to assess glycemic control)
- Blood glucose levels (fasting and postprandial)
- Renal function (e.g., eGFR) periodically, especially in elderly or renally impaired patients.
Doctor Notes
- Emphasize lifestyle modifications (diet, exercise) as foundational therapy for type 2 diabetes.
- Counsel patients on symptoms of hypoglycemia, especially if used with insulin or sulfonylurea.
- Monitor renal function periodically.
Patient Guidelines
- Take your medicine regularly as prescribed by your doctor.
- Do not stop taking the tablet without consulting your doctor, even if you feel well.
- Report any unusual symptoms, especially severe abdominal pain (possible pancreatitis) or severe joint pain.
Missed Dose Advice
If a dose of Ogli 15 mg is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Ogli 15 mg is unlikely to affect your ability to drive or operate machinery alone. However, if taken with other antidiabetic medications (e.g., sulfonylurea, insulin), there is a risk of hypoglycemia, which could impair driving ability. Be aware of symptoms of hypoglycemia.
Lifestyle Advice
- Maintain a balanced diet and regular physical activity as advised by your healthcare provider.
- Monitor your blood glucose levels regularly as instructed.
- Avoid excessive alcohol consumption, which can affect blood sugar.
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Global Brand Names
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