Olacent
Generic Name
Olacetam
Manufacturer
Meditopix Pharma Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| olacent 150 mg tablet | ৳ 350.00 | ৳ 3,500.00 |
Description
Overview of the medicine
Olacent is an antidepressant medication used to treat major depressive disorder (MDD), generalized anxiety disorder (GAD), and panic disorder. It works by affecting certain chemicals in the brain.
Uses & Indications
Dosage
Adults
Initial dose is 50 mg once daily, gradually increased to 150 mg once daily as needed, based on clinical response and tolerability. Max dose 200 mg/day.
Elderly
Similar to adults, but initiate at a lower dose (e.g., 25 mg once daily) and titrate slowly to minimize adverse effects.
Renal_impairment
Dose adjustment may be necessary for patients with moderate to severe renal impairment. Consult physician for specific recommendations.
How to Take
Take Olacent tablet orally once daily, with or without food. Swallow the tablet whole; do not crush, chew, or divide.
Mechanism of Action
Olacent selectively inhibits the reuptake of serotonin and norepinephrine in the brain, thereby increasing the concentration of these neurotransmitters in the synaptic cleft. This leads to enhanced monoaminergic neurotransmission.
Pharmacokinetics
Onset
Therapeutic effects may begin within 1-2 weeks, but full antidepressant effect may take 2-4 weeks or longer.
Excretion
Primarily excreted through urine as metabolites, with a small portion eliminated in feces.
Half life
Approximately 12-15 hours, allowing for once-daily dosing.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 2-4 hours.
Metabolism
Extensively metabolized in the liver, primarily via CYP2D6 and CYP3A4 enzymes, into inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Olacetam or any component of the formulation.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy.
- Severe hepatic impairment.
Drug Interactions
MAOIs
Concurrent use is contraindicated due to risk of serotonin syndrome (e.g., hyperthermia, rigidity, myoclonus, autonomic instability).
Warfarin
May increase anticoagulant effect and risk of bleeding; monitor INR closely.
SSRIs/SNRIs
Increased risk of serotonin syndrome; monitor closely or avoid concomitant use.
CNS Depressants (e.g., alcohol, benzodiazepines)
May potentiate sedative effects; use with caution.
Storage
Store in a cool, dry place below 25°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, dizziness, tachycardia, tremor, and possibly seizures or serotonin syndrome. Management is symptomatic and supportive. Maintain an open airway, monitor cardiac and vital signs. Activated charcoal may be considered.
Pregnancy & Lactation
Category C in pregnancy. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether Olacent is excreted in human milk; use with caution in nursing mothers. Consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Patented
Clinical Trials
Ongoing Phase III and Phase IV clinical trials are exploring Olacetam's efficacy and safety for additional psychiatric conditions and long-term outcomes.
Lab Monitoring
- Regular monitoring of renal and hepatic function, especially in patients with pre-existing impairment.
- Monitor blood pressure periodically, particularly in patients with hypertension.
- Monitor for serum sodium levels, especially in elderly patients or those on diuretics.
Doctor Notes
- Monitor patients for signs of activation of mania/hypomania, especially in those with bipolar disorder.
- Emphasize the importance of gradual dose reduction when discontinuing to prevent withdrawal symptoms.
- Closely observe patients for clinical worsening, suicidality, or unusual behavioral changes, particularly during initiation of therapy or dose changes.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor and do not stop abruptly without consulting your doctor.
- Be aware that it may take several weeks to experience the full benefits of Olacent.
- Report any worsening of depression, suicidal thoughts, or unusual changes in behavior to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. Do not take two doses at once to make up for a missed dose.
Driving Precautions
Olacent may cause dizziness, drowsiness, or blurred vision. Patients should exercise caution when driving or operating hazardous machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain a healthy and balanced diet and engage in regular physical activity.
- Practice stress management techniques such as meditation or yoga.
- Ensure adequate sleep and avoid excessive caffeine intake.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.