Oleanz
Generic Name
Olanzapine
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| oleanz 5 mg tablet | ৳ 2.55 | ৳ 25.50 |
| oleanz 10 mg tablet | ৳ 4.56 | ৳ 45.60 |
Description
Overview of the medicine
Olanzapine is an atypical antipsychotic medication primarily used to treat schizophrenia and bipolar disorder. It helps to restore the balance of certain natural substances (neurotransmitters) in the brain.
Uses & Indications
Dosage
Adults
Schizophrenia: Initially 5-10 mg once daily, target 10 mg/day. Bipolar mania: Initially 10-15 mg once daily.
Elderly
Lower starting dose (e.g., 5 mg/day) may be considered, with cautious titration.
Renal_impairment
No routine dosage adjustment is required, but caution is advised in severe cases.
Hepatic_impairment
Lower starting dose (e.g., 5 mg/day) should be considered, with cautious titration.
How to Take
Take orally once daily with or without food. Oral disintegrating tablets should be placed on the tongue, where it rapidly disintegrates and can be swallowed with or without water.
Mechanism of Action
Olanzapine acts as an antagonist at multiple receptor sites, including dopamine D1, D2, D3, D4, and D5 receptors, and serotonin 5-HT2A, 5-HT2C, 5-HT3, and 5-HT6 receptors. It also has antagonistic effects on muscarinic M1-M5, alpha-1 adrenergic, and histamine H1 receptors.
Pharmacokinetics
Onset
Therapeutic effects may take several days to weeks to fully manifest.
Excretion
Approximately 57% of a dose is excreted in the urine and 30% in the feces.
Half life
Average elimination half-life is 21-54 hours (mean 33 hours).
Absorption
Well absorbed orally; peak plasma concentrations reached in approximately 5-8 hours.
Metabolism
Extensively metabolized in the liver, primarily via direct glucuronidation and by cytochrome P450 enzymes CYP1A2 and CYP2D6.
Side Effects
Contraindications
- Hypersensitivity to olanzapine or any component of the formulation
- Known narrow-angle glaucoma
Drug Interactions
Fluvoxamine
May increase olanzapine levels (CYP1A2 inhibitor); consider reducing olanzapine dose.
Carbamazepine
May decrease olanzapine levels (CYP1A2 inducer); consider increasing olanzapine dose.
Antihypertensives
May potentiate orthostatic hypotension.
Alcohol and other CNS depressants
May potentiate sedative effects and orthostatic hypotension.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include sedation, tachycardia, hypotension, extrapyramidal symptoms, and respiratory depression. Management is supportive, including maintaining airway, oxygenation, ventilation, and cardiovascular monitoring. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved by FDA (USA) and DGDA (Bangladesh)
Patent Status
Generic versions available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of olanzapine for schizophrenia and bipolar disorder. Ongoing research explores other potential uses and long-term effects.
Lab Monitoring
- Fasting glucose and lipid profiles (at baseline, 3 months, then annually)
- Weight (at baseline, monthly for first 3 months, then quarterly)
- Liver function tests (periodically)
- Complete Blood Count (CBC)
Doctor Notes
- Monitor patients regularly for metabolic parameters (weight, blood glucose, lipids) and implement lifestyle interventions.
- Be aware of the risk of Neuroleptic Malignant Syndrome (NMS) and Tardive Dyskinesia.
- Educate patients on the importance of adherence and not discontinuing treatment abruptly.
Patient Guidelines
- Take exactly as prescribed by your doctor, do not alter the dose or stop abruptly.
- Report any unusual side effects, especially uncontrollable movements, fever, muscle rigidity, or changes in mood.
- Avoid driving or operating heavy machinery until you know how this medication affects you.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medication may cause drowsiness, dizziness, or blurred vision. Do not drive or operate heavy machinery until you know how it affects you.
Lifestyle Advice
- Maintain a healthy diet and regular exercise to manage potential weight gain and metabolic risks.
- Avoid alcohol consumption as it can increase sedative effects and dizziness.
- Regularly monitor your weight and blood sugar levels as advised by your doctor.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.