Olmecar Plus
Generic Name
Olmesartan Medoxomil + Hydrochlorothiazide
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| olmecar plus 20 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Olmecar Plus is a combination medicine containing Olmesartan Medoxomil, an Angiotensin II Receptor Blocker (ARB), and Hydrochlorothiazide, a thiazide diuretic. It is used to treat high blood pressure (hypertension) when a single medicine is not enough.
Uses & Indications
Dosage
Adults
Usually one tablet once daily. Dosage may be adjusted after 2-4 weeks. Maximum recommended dose is 40 mg Olmesartan Medoxomil / 25 mg Hydrochlorothiazide once daily.
Elderly
No special dosage adjustment is generally needed, but caution is advised in very elderly patients (≥75 years) due to potential for reduced renal function.
Renal_impairment
Not recommended for patients with severe renal impairment (creatinine clearance <30 ml/min). For moderate impairment, careful monitoring is required, and lower doses may be necessary.
How to Take
Take orally once daily, with or without food, at approximately the same time each day.
Mechanism of Action
Olmesartan Medoxomil blocks the effects of Angiotensin II by selectively binding to the AT1 receptor, leading to vasodilation and reduced blood pressure. Hydrochlorothiazide acts in the renal tubules to inhibit sodium reabsorption, increasing the excretion of sodium, chloride, and water, thereby reducing blood volume and blood pressure.
Pharmacokinetics
Onset
Onset of antihypertensive action for olmesartan is within 1-2 hours, peak effect within 2-4 weeks. For hydrochlorothiazide, onset is about 2 hours, peak at 4 hours.
Excretion
Olmesartan is excreted renally (35-50%) and hepatobiliary (50-65%). Hydrochlorothiazide is primarily excreted unchanged by the kidneys (≥95%).
Half life
Olmesartan: 10-15 hours. Hydrochlorothiazide: 5.6-14.8 hours.
Absorption
Olmesartan Medoxomil is rapidly and completely absorbed from the gastrointestinal tract and rapidly converted to olmesartan. Its bioavailability is approximately 26%. Hydrochlorothiazide is well absorbed from the GI tract (65-75%).
Metabolism
Olmesartan Medoxomil is completely metabolized to olmesartan in the gut mucosa and during first-pass hepatic metabolism. Olmesartan itself undergoes negligible metabolism. Hydrochlorothiazide is not metabolized.
Side Effects
Contraindications
- •Hypersensitivity to Olmesartan Medoxomil, hydrochlorothiazide, or any sulfonylamide-derived drugs.
- •Anuria.
- •Severe renal impairment (creatinine clearance <30 ml/min).
- •Severe hepatic impairment.
- •Pregnancy (second and third trimesters).
- •Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment.
Drug Interactions
NSAIDs
May reduce the diuretic, natriuretic, and antihypertensive effects; risk of worsening renal function.
Lithium
Increased serum lithium concentrations and toxicity.
Corticosteroids
Enhanced electrolyte depletion, particularly hypokalemia.
Other antihypertensive agents
Additive hypotensive effect.
Alcohol, barbiturates, narcotics
Potentiation of orthostatic hypotension.
Cholestyramine and colestipol resins
Impaired absorption of hydrochlorothiazide.
Potassium-sparing diuretics/Potassium supplements
Increased risk of hyperkalemia.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension, dizziness, and electrolyte imbalances (e.g., hypokalemia, hyponatremia). Treatment is symptomatic and supportive. If ingestion is recent, induce emesis or perform gastric lavage. Activated charcoal may be useful. Closely monitor vital signs and serum electrolytes.
Pregnancy & Lactation
Pregnancy: Contraindicated during the second and third trimesters due to fetal toxicity. Discontinue immediately if pregnancy is detected. Lactation: Not recommended. It is unknown if olmesartan is excreted in human milk, but hydrochlorothiazide is. Consider the importance of the drug to the mother versus the risk to the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from the date of manufacture, specific to manufacturer.
Availability
Available in all pharmacies
Approval Status
Approved by DGDA and international regulatory bodies
Patent Status
Off-patent, generics available
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Global Brand Names
International brand names for this medicine
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