Olmesta
Generic Name
Olmesartan Medoxomil
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| olmesta 20 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Olmesta 20 mg Tablet contains Olmesartan Medoxomil, an angiotensin II receptor blocker (ARB) used to treat high blood pressure (hypertension). It helps to relax blood vessels, allowing blood to flow more easily and lowering blood pressure, thereby reducing the risk of heart attack and stroke.
Uses & Indications
Dosage
Adults
Initial dose is 20 mg once daily. The dose may be increased to a maximum of 40 mg once daily if blood pressure is not adequately controlled. May be taken with or without food.
Elderly
No initial dosage adjustment is usually necessary for elderly patients. However, caution should be exercised.
Renal_impairment
In patients with moderate to severe renal impairment (creatinine clearance <40 mL/min), a lower initial dose of 10 mg once daily is recommended. Not recommended in severe impairment or end-stage renal disease.
How to Take
Olmesta 20 mg Tablet should be taken orally, once daily, with or without food. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet.
Mechanism of Action
Olmesartan Medoxomil is an inactive prodrug that is hydrolyzed to its active metabolite, Olmesartan, during absorption from the gastrointestinal tract. Olmesartan selectively blocks the binding of angiotensin II to the AT1 receptor in various tissues, including vascular smooth muscle, adrenal glands, and kidneys. This blockade prevents the vasoconstrictive and aldosterone-secreting effects of angiotensin II, leading to vasodilation, decreased peripheral resistance, and reduced blood pressure.
Pharmacokinetics
Onset
Antihypertensive effect begins within 2 weeks, with maximum effect observed after about 8 weeks of therapy.
Excretion
Approximately 35-50% excreted via urine and the remainder via bile/feces.
Half life
Approximately 13 hours.
Absorption
Rapidly and completely converted to active Olmesartan during absorption from the GI tract. Absolute bioavailability of Olmesartan is approximately 26%. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
No significant metabolism by CYP450 enzymes. Small fraction metabolized in the gut.
Side Effects
Contraindications
- •Pregnancy (especially second and third trimesters)
- •Bilateral renal artery stenosis
- •Hypersensitivity to Olmesartan or any component of the formulation
- •Concomitant use with Aliskiren in patients with diabetes or renal impairment
Drug Interactions
NSAIDs
May reduce the antihypertensive effect of Olmesartan and increase the risk of renal function deterioration, especially in elderly, volume-depleted, or renally impaired patients.
Lithium
Increased serum lithium concentrations and lithium toxicity have been reported with concomitant use. Monitor lithium levels.
Aliskiren
Concomitant use is contraindicated in patients with diabetes or renal impairment due to increased risk of hyperkalemia, hypotension, and renal impairment.
Potassium-sparing diuretics and potassium supplements
May lead to increased serum potassium levels (hyperkalemia).
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
The most likely manifestation of overdose is hypotension and tachycardia; bradycardia could occur. Treatment is symptomatic and supportive. If ingestion is recent, induce emesis or perform gastric lavage. Administer activated charcoal to reduce absorption. Monitor vital signs closely.
Pregnancy & Lactation
Use of Olmesartan Medoxomil is contraindicated during the second and third trimesters of pregnancy due to the risk of fetal harm or death. It is not recommended during the first trimester. It is not known whether Olmesartan is excreted in human milk; therefore, breastfeeding is not recommended.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture when stored under recommended conditions.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by FDA (USA) and DGDA (Bangladesh)
Patent Status
Generics available; original patent expired
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Global Brand Names
International brand names for this medicine
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