Olmesta
Generic Name
Olmesartan Medoxomil
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| olmesta 20 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Olmesta 20 mg Tablet contains Olmesartan Medoxomil, an angiotensin II receptor blocker (ARB) used to treat high blood pressure (hypertension). It helps to relax blood vessels, allowing blood to flow more easily and lowering blood pressure, thereby reducing the risk of heart attack and stroke.
Uses & Indications
Dosage
Adults
Initial dose is 20 mg once daily. The dose may be increased to a maximum of 40 mg once daily if blood pressure is not adequately controlled. May be taken with or without food.
Elderly
No initial dosage adjustment is usually necessary for elderly patients. However, caution should be exercised.
Renal_impairment
In patients with moderate to severe renal impairment (creatinine clearance <40 mL/min), a lower initial dose of 10 mg once daily is recommended. Not recommended in severe impairment or end-stage renal disease.
How to Take
Olmesta 20 mg Tablet should be taken orally, once daily, with or without food. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet.
Mechanism of Action
Olmesartan Medoxomil is an inactive prodrug that is hydrolyzed to its active metabolite, Olmesartan, during absorption from the gastrointestinal tract. Olmesartan selectively blocks the binding of angiotensin II to the AT1 receptor in various tissues, including vascular smooth muscle, adrenal glands, and kidneys. This blockade prevents the vasoconstrictive and aldosterone-secreting effects of angiotensin II, leading to vasodilation, decreased peripheral resistance, and reduced blood pressure.
Pharmacokinetics
Onset
Antihypertensive effect begins within 2 weeks, with maximum effect observed after about 8 weeks of therapy.
Excretion
Approximately 35-50% excreted via urine and the remainder via bile/feces.
Half life
Approximately 13 hours.
Absorption
Rapidly and completely converted to active Olmesartan during absorption from the GI tract. Absolute bioavailability of Olmesartan is approximately 26%. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
No significant metabolism by CYP450 enzymes. Small fraction metabolized in the gut.
Side Effects
Contraindications
- Pregnancy (especially second and third trimesters)
- Bilateral renal artery stenosis
- Hypersensitivity to Olmesartan or any component of the formulation
- Concomitant use with Aliskiren in patients with diabetes or renal impairment
Drug Interactions
NSAIDs
May reduce the antihypertensive effect of Olmesartan and increase the risk of renal function deterioration, especially in elderly, volume-depleted, or renally impaired patients.
Lithium
Increased serum lithium concentrations and lithium toxicity have been reported with concomitant use. Monitor lithium levels.
Aliskiren
Concomitant use is contraindicated in patients with diabetes or renal impairment due to increased risk of hyperkalemia, hypotension, and renal impairment.
Potassium-sparing diuretics and potassium supplements
May lead to increased serum potassium levels (hyperkalemia).
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
The most likely manifestation of overdose is hypotension and tachycardia; bradycardia could occur. Treatment is symptomatic and supportive. If ingestion is recent, induce emesis or perform gastric lavage. Administer activated charcoal to reduce absorption. Monitor vital signs closely.
Pregnancy & Lactation
Use of Olmesartan Medoxomil is contraindicated during the second and third trimesters of pregnancy due to the risk of fetal harm or death. It is not recommended during the first trimester. It is not known whether Olmesartan is excreted in human milk; therefore, breastfeeding is not recommended.
Side Effects
Contraindications
- Pregnancy (especially second and third trimesters)
- Bilateral renal artery stenosis
- Hypersensitivity to Olmesartan or any component of the formulation
- Concomitant use with Aliskiren in patients with diabetes or renal impairment
Drug Interactions
NSAIDs
May reduce the antihypertensive effect of Olmesartan and increase the risk of renal function deterioration, especially in elderly, volume-depleted, or renally impaired patients.
Lithium
Increased serum lithium concentrations and lithium toxicity have been reported with concomitant use. Monitor lithium levels.
Aliskiren
Concomitant use is contraindicated in patients with diabetes or renal impairment due to increased risk of hyperkalemia, hypotension, and renal impairment.
Potassium-sparing diuretics and potassium supplements
May lead to increased serum potassium levels (hyperkalemia).
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
The most likely manifestation of overdose is hypotension and tachycardia; bradycardia could occur. Treatment is symptomatic and supportive. If ingestion is recent, induce emesis or perform gastric lavage. Administer activated charcoal to reduce absorption. Monitor vital signs closely.
Pregnancy & Lactation
Use of Olmesartan Medoxomil is contraindicated during the second and third trimesters of pregnancy due to the risk of fetal harm or death. It is not recommended during the first trimester. It is not known whether Olmesartan is excreted in human milk; therefore, breastfeeding is not recommended.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture when stored under recommended conditions.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by FDA (USA) and DGDA (Bangladesh)
Patent Status
Generics available; original patent expired
Clinical Trials
Olmesartan Medoxomil has been extensively studied in various clinical trials demonstrating its efficacy and safety in the treatment of hypertension, including its effects on cardiovascular outcomes (e.g., in the ROADMAP and ARTEMIS trials).
Lab Monitoring
- Serum creatinine and BUN (blood urea nitrogen)
- Serum potassium levels
- Liver function tests (periodically)
Doctor Notes
- Regularly monitor renal function and serum potassium, especially in patients with compromised renal function or those taking NSAIDs or potassium-sparing diuretics.
- Counsel patients on the importance of adherence to therapy and lifestyle modifications.
- Avoid use in pregnant women; discontinue immediately if pregnancy is detected.
- Consider combination therapy if blood pressure is not adequately controlled with monotherapy.
Patient Guidelines
- Take your medicine regularly at the same time each day, as directed by your doctor.
- Do not stop taking Olmesartan Medoxomil suddenly without consulting your doctor, even if you feel well.
- Monitor your blood pressure regularly and report any significant changes to your doctor.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Olmesta 20 mg Tablet may cause dizziness, especially at the start of treatment or when the dose is increased. If you experience dizziness, avoid driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Adopt a healthy lifestyle including a balanced diet rich in fruits and vegetables, and low in saturated fats and sodium.
- Engage in regular physical activity as advised by your doctor.
- Avoid smoking and limit alcohol consumption to help manage blood pressure.
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