olopred-plus
Generic Name
olopred-plus-05-03-suspension
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| olopred plus 05 03 suspension | ৳ 200.00 | N/A |
Description
Overview of the medicine
Olopred-plus 05-03 Suspension is an oral medication combining Olopatadine, an H1-receptor antagonist and mast cell stabilizer, with Prednisolone, a potent corticosteroid. It is indicated for the symptomatic relief of allergic and inflammatory conditions.
Uses & Indications
Dosage
Adults
Usually 5-10 ml orally once or twice daily, or as directed by physician. Dosage may vary based on condition severity.
Elderly
Lower initial doses recommended; monitor for adverse effects.
Renal_impairment
Use with caution. Dosage adjustment may be necessary based on renal function.
How to Take
Administer orally. Shake the bottle well before each use. Can be taken with or without food.
Mechanism of Action
Olopatadine selectively blocks histamine H1 receptors, preventing the effects of histamine and stabilizes mast cells to inhibit the release of inflammatory mediators. Prednisolone, a glucocorticoid, acts by binding to specific intracellular glucocorticoid receptors, modifying gene expression to exert potent anti-inflammatory and immunosuppressive effects.
Pharmacokinetics
Onset
Olopatadine: Within 30-60 minutes. Prednisolone: Within 1-2 hours.
Excretion
Olopatadine: Primarily renal (65% unchanged drug and metabolites). Prednisolone: Primarily renal.
Half life
Olopatadine: 8-12 hours. Prednisolone: Plasma half-life 2-3 hours; biological half-life 18-36 hours.
Absorption
Olopatadine: Rapidly absorbed, peak plasma concentrations 1-2 hours. Prednisolone: Readily and rapidly absorbed, peak plasma concentrations 1-2 hours.
Metabolism
Olopatadine: Primarily by oxidation, minor CYP450. Prednisolone: Primarily hepatic to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Olopatadine, Prednisolone or any component of the formulation
- Systemic fungal infections
- Untreated bacterial, viral or parasitic infections
- Live attenuated vaccines during immunosuppressive doses of corticosteroids
Drug Interactions
Olopatadine
Concomitant use with alcohol or other CNS depressants may enhance drowsiness.
Prednisolone
CYP3A4 inducers (e.g., rifampin, phenobarbital) may decrease Prednisolone levels. CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) may increase Prednisolone levels. Concomitant use with NSAIDs increases risk of GI ulceration. Live attenuated vaccines should not be given.
Storage
Store below 30°C, protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include increased side effects such as drowsiness, hypertension, fluid retention, or hyperglycemia. Management is primarily supportive and symptomatic. Gastric lavage or activated charcoal may be considered soon after acute ingestion.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Both components are excreted in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Olopatadine, Prednisolone or any component of the formulation
- Systemic fungal infections
- Untreated bacterial, viral or parasitic infections
- Live attenuated vaccines during immunosuppressive doses of corticosteroids
Drug Interactions
Olopatadine
Concomitant use with alcohol or other CNS depressants may enhance drowsiness.
Prednisolone
CYP3A4 inducers (e.g., rifampin, phenobarbital) may decrease Prednisolone levels. CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) may increase Prednisolone levels. Concomitant use with NSAIDs increases risk of GI ulceration. Live attenuated vaccines should not be given.
Storage
Store below 30°C, protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose may include increased side effects such as drowsiness, hypertension, fluid retention, or hyperglycemia. Management is primarily supportive and symptomatic. Gastric lavage or activated charcoal may be considered soon after acute ingestion.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Both components are excreted in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Clinical trials have demonstrated the efficacy and safety of both Olopatadine and Prednisolone individually in their respective therapeutic areas. Combination therapy is often supported by the synergistic effects of these agents.
Lab Monitoring
- Blood glucose levels
- Electrolyte levels
- Blood pressure
- Bone mineral density (for long-term use of corticosteroids)
Doctor Notes
- Educate patients about the importance of not stopping corticosteroids abruptly.
- Monitor for signs of infection, especially in immunocompromised patients.
- Consider bone protection strategies for long-term corticosteroid therapy.
Patient Guidelines
- Shake the bottle well before each use.
- Do not stop taking this medication abruptly, especially after prolonged use, consult your doctor for gradual dose reduction.
- Report any unusual side effects to your doctor immediately.
- Avoid contact with sick people during treatment.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how it affects you.
Lifestyle Advice
- Maintain a healthy and balanced diet.
- Identify and avoid known allergens.
- Regular exercise (if medically permitted) to maintain bone health for long-term corticosteroid use.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.