Olpres
Generic Name
Olanzapine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| olpres 20 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Olpres 20 mg Tablet contains Olanzapine, an atypical antipsychotic medicine used to treat mental health conditions like schizophrenia and bipolar disorder. It helps restore the balance of certain natural substances (neurotransmitters) in the brain.
Uses & Indications
Dosage
Adults
Schizophrenia: Initially 10-20 mg once daily. Bipolar I Disorder: Initially 10-15 mg once daily as monotherapy or 10 mg once daily in combination therapy. Dosage adjustment based on clinical response and tolerability, typically not exceeding 20 mg/day.
Elderly
A lower starting dose (e.g., 5 mg/day) may be considered, with careful titration and monitoring due to increased sensitivity and potential for adverse effects.
Renal_impairment
No specific dose adjustments are required for mild to moderate renal impairment, but caution is advised. For severe impairment, consultation with a specialist is recommended.
How to Take
Administer orally once daily, with or without food. The tablet should be swallowed whole; do not chew or crush. Consistency in timing of administration is recommended.
Mechanism of Action
Olanzapine acts as an antagonist at multiple receptors including serotonin 5-HT2A, dopamine D1/D2/D3/D4, alpha1-adrenergic, histamine H1, and muscarinic M1-5 receptors. Its antipsychotic effect is primarily attributed to its antagonism of dopamine D2 and serotonin 5-HT2A receptors.
Pharmacokinetics
Onset
Antipsychotic effects typically manifest within days to weeks, though sedation can be immediate.
Excretion
Approximately 57% of the dose is excreted in urine and 30% in feces, mainly as metabolites.
Half life
Approximately 21-54 hours (average 33 hours).
Absorption
Well absorbed orally; peak plasma concentrations reached in approximately 5-8 hours.
Metabolism
Extensively metabolized in the liver, primarily via CYP1A2 and glucuronidation (UGT).
Side Effects
Contraindications
- Known hypersensitivity to olanzapine or any component of the formulation
- Patients with known angle-closure glaucoma or at risk of it, due to its anticholinergic effects
Drug Interactions
Fluvoxamine
May increase olanzapine plasma levels due to CYP1A2 inhibition, requiring a dosage reduction of olanzapine.
Carbamazepine
May decrease olanzapine plasma levels due to CYP1A2 induction, potentially requiring an increase in olanzapine dosage.
Anticholinergics
Potentiation of anticholinergic effects (e.g., constipation, dry mouth, urinary retention).
CNS Depressants (e.g., alcohol, benzodiazepines)
Co-administration with other centrally acting agents or alcohol may potentiate CNS depressant effects.
Storage
Store below 30°C (86°F) in a dry place, protected from direct light and moisture. Keep out of the sight and reach of children.
Overdose
Symptoms of overdose include drowsiness, blurred vision, tachycardia, agitation, delirium, extrapyramidal symptoms, and hypotension. Severe cases may lead to respiratory depression or coma. Treatment is supportive and symptomatic; there is no specific antidote for olanzapine overdose. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Neonates exposed to antipsychotic drugs during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms. It is not recommended during breastfeeding as olanzapine is excreted in breast milk.
Side Effects
Contraindications
- Known hypersensitivity to olanzapine or any component of the formulation
- Patients with known angle-closure glaucoma or at risk of it, due to its anticholinergic effects
Drug Interactions
Fluvoxamine
May increase olanzapine plasma levels due to CYP1A2 inhibition, requiring a dosage reduction of olanzapine.
Carbamazepine
May decrease olanzapine plasma levels due to CYP1A2 induction, potentially requiring an increase in olanzapine dosage.
Anticholinergics
Potentiation of anticholinergic effects (e.g., constipation, dry mouth, urinary retention).
CNS Depressants (e.g., alcohol, benzodiazepines)
Co-administration with other centrally acting agents or alcohol may potentiate CNS depressant effects.
Storage
Store below 30°C (86°F) in a dry place, protected from direct light and moisture. Keep out of the sight and reach of children.
Overdose
Symptoms of overdose include drowsiness, blurred vision, tachycardia, agitation, delirium, extrapyramidal symptoms, and hypotension. Severe cases may lead to respiratory depression or coma. Treatment is supportive and symptomatic; there is no specific antidote for olanzapine overdose. Gastric lavage and activated charcoal may be considered.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Neonates exposed to antipsychotic drugs during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms. It is not recommended during breastfeeding as olanzapine is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the manufacturing date, consult the packaging for specific expiry details.
Availability
Available in retail pharmacies and hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Patent expired; generic versions available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of olanzapine in the acute and maintenance treatment of schizophrenia and bipolar I disorder. Ongoing post-marketing surveillance and studies continue to gather information on long-term effects and specific patient populations.
Lab Monitoring
- Fasting glucose levels (baseline and periodically, e.g., every 3-6 months)
- Lipid profile (cholesterol, triglycerides; baseline and periodically)
- Weight and BMI (baseline and regularly)
- Liver function tests (LFTs) periodically, especially in patients with pre-existing hepatic impairment
Doctor Notes
- Regularly monitor patients for metabolic side effects including weight gain, fasting glucose, and lipid profile. Provide appropriate lifestyle counseling.
- Assess for abnormal involuntary movements (e.g., tardive dyskinesia) periodically, especially with long-term treatment.
- Educate patients and caregivers on the importance of adherence to treatment and avoiding abrupt discontinuation.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor, even if you feel better.
- Do not stop taking it suddenly without consulting your doctor, as this can lead to withdrawal symptoms or relapse.
- Inform your doctor immediately if you experience any uncontrollable muscle movements, fever, muscle stiffness, or confusion.
Missed Dose Advice
If you miss a dose of Olpres, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Olpres may cause drowsiness, dizziness, or blurred vision, especially at the start of treatment. Avoid driving or operating heavy machinery until you know how this medicine affects your ability to perform such tasks safely.
Lifestyle Advice
- Maintain a healthy and balanced diet and engage in regular physical activity to manage potential weight gain and metabolic side effects.
- Avoid alcohol consumption and other CNS depressants while taking this medication as it can increase drowsiness.
- Regularly monitor your weight, blood sugar, and cholesterol levels as advised by your doctor.
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