Olvance
Generic Name
Olmesartan Medoxomil
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| olvance 20 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Olvance 20 mg Tablet contains Olmesartan Medoxomil, an angiotensin II receptor blocker (ARB), used to treat high blood pressure (hypertension). It helps to lower blood pressure by relaxing blood vessels, allowing blood to flow more easily.
Uses & Indications
Dosage
Adults
The usual recommended starting dose of Olmesartan Medoxomil is 20 mg once daily. The dose can be increased to 40 mg once daily if blood pressure is not adequately controlled after 2 weeks.
Elderly
No initial dose adjustment is required for elderly patients. However, caution should be exercised with dose increases.
Renal_impairment
Patients with moderate to severe renal impairment (creatinine clearance <40 mL/min) should be initiated with 10 mg once daily. Higher doses should be used with caution.
How to Take
Administer orally once daily with or without food. Swallow the tablet whole with water.
Mechanism of Action
Olmesartan is a selective AT1 subtype angiotensin II receptor antagonist. It blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, including vascular smooth muscle and the adrenal gland. This leads to vasodilation, decreased peripheral resistance, and reduced blood pressure.
Pharmacokinetics
Onset
Within 2 hours
Excretion
Approximately 35-50% excreted in urine and 50-65% in feces via bile.
Half life
Approximately 13 hours
Absorption
Rapidly and completely converted to active olmesartan during absorption from the gastrointestinal tract. Bioavailability is approximately 26%. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
No significant metabolism by the cytochrome P450 system. It is hydrolyzed to active olmesartan in the GI tract.
Side Effects
Contraindications
- Hypersensitivity to Olmesartan Medoxomil or any component of the product.
- Pregnancy (especially second and third trimesters).
- Severe hepatic impairment.
- Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR <60 mL/min/1.73 m²).
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity.
Aliskiren
Increased risk of hypotension, hyperkalemia, and renal impairment (especially in diabetic or renally impaired patients).
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal impairment.
Potassium-sparing diuretics/potassium supplements
Increased risk of hyperkalemia.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are likely to be hypotension and tachycardia; bradycardia could occur from parasympathetic stimulation. Management involves symptomatic and supportive treatment, including IV fluids and vasopressors if severe hypotension occurs.
Pregnancy & Lactation
Pregnancy: Olmesartan is contraindicated in the second and third trimesters of pregnancy. It can cause fetal harm. Lactation: Not recommended during breastfeeding due to potential risk to the nursing infant.
Side Effects
Contraindications
- Hypersensitivity to Olmesartan Medoxomil or any component of the product.
- Pregnancy (especially second and third trimesters).
- Severe hepatic impairment.
- Concomitant use with aliskiren in patients with diabetes mellitus or renal impairment (GFR <60 mL/min/1.73 m²).
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity.
Aliskiren
Increased risk of hypotension, hyperkalemia, and renal impairment (especially in diabetic or renally impaired patients).
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
May reduce the antihypertensive effect and increase the risk of renal impairment.
Potassium-sparing diuretics/potassium supplements
Increased risk of hyperkalemia.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are likely to be hypotension and tachycardia; bradycardia could occur from parasympathetic stimulation. Management involves symptomatic and supportive treatment, including IV fluids and vasopressors if severe hypotension occurs.
Pregnancy & Lactation
Pregnancy: Olmesartan is contraindicated in the second and third trimesters of pregnancy. It can cause fetal harm. Lactation: Not recommended during breastfeeding due to potential risk to the nursing infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic versions available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Olmesartan Medoxomil in reducing blood pressure and cardiovascular risk in patients with hypertension.
Lab Monitoring
- Serum electrolytes (especially potassium)
- Renal function (BUN, creatinine, GFR)
- Liver function tests (periodically, if clinically indicated)
Doctor Notes
- Regularly monitor blood pressure and renal function.
- Advise patients on lifestyle modifications.
- Caution when prescribing with NSAIDs or potassium-sparing agents.
- Contraindicated in pregnancy.
Patient Guidelines
- Take the medicine regularly as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor, even if you feel well.
- Inform your doctor about all other medications you are taking.
- Monitor your blood pressure regularly.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or fatigue, especially at the start of treatment or when changing dosage. Patients should be cautioned about operating machinery or driving until they know how Olmesartan affects them.
Lifestyle Advice
- Adopt a healthy diet (low sodium, high fruits/vegetables).
- Engage in regular physical activity.
- Maintain a healthy weight.
- Avoid smoking and limit alcohol intake.
- Manage stress effectively.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.