Omastin
Generic Name
Omastinumab 200 mg Injection
Manufacturer
Medix Pharma Inc.
Country
United States
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| omastin 200 mg injection | ৳ 200.00 | N/A |
Description
Overview of the medicine
Omastin is a monoclonal antibody used in the treatment of various cancers. It works by targeting the PD-1 (programmed cell death-1) protein on T-cells, thereby enhancing the immune system's ability to fight cancer cells.
Uses & Indications
Dosage
Adults
200 mg administered intravenously over 30 minutes every 3 weeks, or 400 mg every 6 weeks, until disease progression or unacceptable toxicity.
Elderly
No specific dose adjustment required based on age; monitor for adverse reactions.
Renal_impairment
No dose adjustment recommended for mild to moderate renal impairment. Data for severe impairment is limited.
How to Take
Administer as an intravenous infusion over 30 minutes. Do not administer as an intravenous push or bolus.
Mechanism of Action
Omastinumab is an anti-PD-1 monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2. This blockade releases PD-1 pathway-mediated inhibition of the immune response, including anti-tumor immune response, leading to tumor regression.
Pharmacokinetics
Onset
Immune-mediated effects can be seen within weeks, clinical response may take longer.
Excretion
Primarily through cellular uptake and degradation.
Half life
Approximately 2-3 weeks (14-21 days).
Absorption
Administered intravenously, leading to complete systemic bioavailability.
Metabolism
Catabolized via general protein degradation pathways; not metabolized by cytochrome P450 enzymes.
Side Effects
Contraindications
- Known hypersensitivity to Omastinumab or any excipients.
- Patients with severe active autoimmune disease requiring systemic immunosuppression.
Drug Interactions
Systemic Corticosteroids/Immunosuppressants
May interfere with Omastinumab's activity; avoid use prior to initiation of Omastinumab.
Storage
Store refrigerated at 2°C to 8°C (36°F to 46°F) in the original carton to protect from light. Do not freeze. Do not shake.
Overdose
There is no specific antidote for Omastinumab overdose. In case of an overdose, monitor patients closely for signs and symptoms of adverse reactions and provide symptomatic and supportive treatment.
Pregnancy & Lactation
Pregnancy Category D. Omastinumab can cause fetal harm. Advise pregnant women of the potential risk to the fetus. It is unknown if Omastinumab is excreted in human milk; due to the potential for serious adverse reactions in breastfed infants, advise women not to breastfeed during treatment and for 5 months after the last dose.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months when stored as recommended.
Availability
Specialized Hospital Pharmacies, Oncology Centers
Approval Status
Approved (hypothetical)
Patent Status
Under patent
Clinical Trials
Omastinumab has been investigated in multiple pivotal phase 3 clinical trials demonstrating efficacy and safety across various tumor types, often showing improved overall survival and progression-free survival compared to standard therapies.
Lab Monitoring
- Liver function tests (ALT, AST, bilirubin)
- Thyroid function tests (TSH, free T4)
- Renal function tests (creatinine)
- Electrolytes
- Blood glucose
Doctor Notes
- Careful monitoring for immune-related adverse events is crucial.
- Patients should be educated on early symptoms of adverse reactions.
- Consider corticosteroid therapy for management of severe immune-mediated adverse reactions.
Patient Guidelines
- Report any new or worsening symptoms immediately to your healthcare provider.
- Do not stop treatment without consulting your doctor.
- Understand the signs of immune-mediated adverse reactions.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. Adjust the dosing schedule to maintain the prescribed interval.
Driving Precautions
Omastinumab may cause fatigue or dizziness. Patients should be advised to exercise caution when driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent infections.
- Stay hydrated and follow a balanced diet.
- Avoid unapproved herbal supplements without medical advice.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.