Omenix
Generic Name
Omeprazole 40 mg Injection
Manufacturer
Acme Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| omenix 40 mg injection | ৳ 90.00 | N/A |
Description
Overview of the medicine
Omenix 40 mg Injection contains Omeprazole, a proton pump inhibitor that reduces the amount of acid produced in the stomach. It is used to treat conditions caused by too much stomach acid.
Uses & Indications
Dosage
Adults
Usually 40 mg IV once daily. For severe cases or Zollinger-Ellison syndrome, up to 40 mg IV twice daily.
Elderly
No specific dosage adjustment usually needed, but monitor closely.
Renal_impairment
No dosage adjustment required.
How to Take
Administer as a slow intravenous injection (over 2.5 to 5 minutes) or as an intravenous infusion (over 20-30 minutes) after reconstitution with appropriate solvent.
Mechanism of Action
Omeprazole selectively inhibits the H+/K+-ATPase enzyme system (the proton pump) at the secretory surface of the gastric parietal cells. This irreversible inhibition reduces gastric acid secretion.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Mainly excreted in the urine (approx. 80%) and feces (approx. 20%).
Half life
Approximately 0.5-1.5 hours.
Absorption
Rapidly absorbed after intravenous administration, high bioavailability.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C19 and CYP3A4 enzymes.
Side Effects
Contraindications
- Hypersensitivity to omeprazole, substituted benzimidazoles, or any component of the formulation
- Concomitant use with nelfinavir
Drug Interactions
Warfarin
May increase INR and bleeding risk. Monitor closely.
Nelfinavir
Contraindicated, significantly reduces nelfinavir plasma levels.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel. Avoid concomitant use.
Methotrexate
May increase methotrexate levels, especially with high doses.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Reconstituted solution should be used within 4 hours if kept at room temperature.
Overdose
Symptoms of overdose may include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and potential benefits outweigh the risks. Excreted in breast milk, use with caution during lactation or consider an alternative.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months (unreconstituted)
Availability
Hospitals, Pharmacies
Approval Status
Approved (Hypothetical Local Approval)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of omeprazole for various acid-related disorders. Studies have shown significant healing rates for ulcers and symptom relief for GERD.
Lab Monitoring
- Magnesium levels (for long-term use)
- Vitamin B12 levels (for long-term use)
- INR for patients on warfarin
Doctor Notes
- Confirm no concomitant use of nelfinavir due to significant interaction.
- Monitor patients on long-term therapy for magnesium and vitamin B12 levels.
- Advise patients about potential risks of C. difficile infection if unexplained diarrhea occurs.
Patient Guidelines
- Do not stop treatment abruptly without consulting your doctor.
- Report any unusual symptoms, especially severe or persistent diarrhea.
- Inform your doctor about all other medications, including over-the-counter drugs and herbal supplements, you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods like spicy, fatty foods, chocolate, and caffeine to manage GERD symptoms.
- Elevate the head of your bed if you experience nighttime reflux.
- Quit smoking and limit alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.