Ometor
Generic Name
Omeprazole
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ometor 20 mg capsule | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Omeprazole 20 mg capsule is a proton pump inhibitor (PPI) used to treat conditions caused by too much stomach acid. It works by decreasing the amount of acid your stomach makes, thereby relieving symptoms like heartburn, difficulty swallowing, and persistent cough, and allowing the esophagus to heal.
Uses & Indications
Dosage
Adults
GERD: 20 mg once daily for 4-8 weeks. Duodenal ulcer: 20 mg once daily for 2-4 weeks. Gastric ulcer: 20 mg once daily for 4-8 weeks. Zollinger-Ellison syndrome: Initial 60 mg once daily, adjust as needed. H. pylori eradication: 20 mg twice daily with antibiotics for 7-14 days.
Elderly
No dosage adjustment is generally required, but caution is advised due to potential age-related decrease in elimination.
Renal_impairment
No dosage adjustment is required for patients with impaired renal function.
How to Take
Take the capsule whole with a glass of water, preferably in the morning before a meal. Do not chew or crush the capsule.
Mechanism of Action
Omeprazole is a substituted benzimidazole that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase enzyme system (the proton pump) at the secretory surface of the gastric parietal cells. It is a prodrug that is activated in the acidic environment of the parietal cell canaliculi.
Pharmacokinetics
Onset
Within 1 hour (antisecretory effect)
Excretion
Mainly excreted in the urine (approx. 77%) as metabolites and in the feces (approx. 20%) as metabolites.
Half life
Approximately 0.5-1 hour
Absorption
Rapidly absorbed from the gastrointestinal tract, peak plasma concentrations occur within 1-2 hours. Bioavailability is about 30-40% but increases with repeated dosing.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 system (primarily CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to omeprazole or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Diazepam
Decreased metabolism and increased plasma levels of diazepam.
Warfarin
Increased INR/prothrombin time; monitor closely.
Clopidogrel
Omeprazole can reduce the antiplatelet effect of clopidogrel.
Methotrexate
Increased plasma levels of methotrexate, especially with high doses.
Atazanavir, Nelfinavir
Reduced absorption and efficacy of these antiretrovirals.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and reversible, including nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if potential benefit justifies potential risk to the fetus. Excreted in breast milk; use with caution in lactating mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months (check packaging for exact date)
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials demonstrating efficacy and safety in various acid-related disorders.
Lab Monitoring
- Monitor magnesium levels in patients on long-term therapy or concomitant with other drugs that can cause hypomagnesemia.
Doctor Notes
- Consider lowest effective dose for shortest duration.
- Evaluate need for continued therapy periodically.
- Monitor for interactions, especially with clopidogrel and warfarin.
- Advise patients on lifestyle modifications to complement therapy.
Patient Guidelines
- Take the medication exactly as prescribed.
- Do not stop taking the medication abruptly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Omeprazole is generally not expected to affect the ability to drive or operate machinery. However, if side effects like dizziness or visual disturbances occur, caution should be exercised.
Lifestyle Advice
- Avoid foods and drinks that trigger heartburn (e.g., spicy foods, caffeine, alcohol).
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.