Onbrez
Generic Name
Indacaterol
Manufacturer
Novartis
Country
Switzerland (originator)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| onbrez 300 mcg inhalation capsule | ৳ 126.50 | ৳ 1,265.00 |
Description
Overview of the medicine
Onbrez 300 mcg is an inhalation capsule containing Indacaterol, a long-acting beta2-adrenergic agonist (LABA), used for the maintenance treatment of chronic obstructive pulmonary disease (COPD). It is not for the relief of acute bronchospasm.
Uses & Indications
Dosage
Adults
One 300 mcg capsule inhaled once daily using the Onbrez Breezhaler device. Do not swallow the capsule.
Elderly
No dosage adjustment is required in elderly patients.
Renal_impairment
No dosage adjustment is necessary for patients with renal impairment.
How to Take
For oral inhalation only, using the specific Onbrez Breezhaler device. The capsule must not be swallowed. Administer at the same time each day.
Mechanism of Action
Indacaterol selectively stimulates beta2-adrenergic receptors in the lung, leading to relaxation of bronchial smooth muscle and bronchodilation. It provides 24-hour bronchodilation when administered once daily.
Pharmacokinetics
Onset
Within 5 minutes
Excretion
Mainly via feces (90%), with a smaller portion excreted renally (10%).
Half life
Approximately 40-56 hours
Absorption
Rapidly absorbed after inhalation. Peak plasma concentrations are reached within 15-30 minutes.
Metabolism
Primarily via UGT1A1 and to a lesser extent CYP3A4. Main metabolite is hydroxylated indacaterol.
Side Effects
Contraindications
- Hypersensitivity to indacaterol or any excipients
- Not for the treatment of acute bronchospasm or status asthmaticus
- Avoid use in patients with severe milk protein allergy due to lactose content
Drug Interactions
Beta-blockers
May reduce the bronchodilatory effect of indacaterol and should be used with caution, preferably cardioselective beta-blockers.
Other sympathomimetics
May potentiate adverse cardiovascular effects.
Non-potassium-sparing diuretics
May increase the risk of hypokalemia.
MAO inhibitors, tricyclic antidepressants
May potentiate the action of indacaterol on the cardiovascular system.
Storage
Store in a dry place below 30°C. Protect from moisture and heat. Keep out of reach of children.
Overdose
Symptoms of overdose may include exaggeration of typical beta2-adrenergic effects, such as tachycardia, tremors, palpitations, headache, nausea, vomiting, drowsiness, and hypokalemia. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Category C (old classification). Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Use with caution during lactation; it is unknown if indacaterol is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months when stored as recommended.
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA)
Patent Status
Varies by region; initial patents expired, but formulation patents may exist.
Clinical Trials
Extensive clinical trials (e.g., INHANCE, INTRUST, INTENSIFY) demonstrated efficacy and safety in COPD patients.
Lab Monitoring
- Monitor for signs of hypokalemia and hyperglycemia, especially in susceptible patients.
Doctor Notes
- Emphasize proper inhalation technique with the Breezhaler device.
- Remind patients that Onbrez is a maintenance therapy, not for acute exacerbations.
- Counsel patients on potential drug interactions, especially with beta-blockers.
Patient Guidelines
- Do not swallow the capsules; they are for inhalation only.
- Use the Onbrez Breezhaler device correctly as instructed by your doctor or pharmacist.
- Do not use for sudden breathing problems; this is a maintenance medicine.
- If your symptoms worsen or you need to use your rescue inhaler more often, contact your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as possible. If it is almost time for the next dose, skip the missed dose and return to your regular dosing schedule. Do not take two doses at once.
Driving Precautions
No or negligible influence on the ability to drive and use machines. However, if side effects like dizziness occur, patients should exercise caution.
Lifestyle Advice
- Quit smoking to improve COPD symptoms and overall lung health.
- Avoid irritants like smoke, dust, and pollutants.
- Maintain a healthy lifestyle with regular exercise and a balanced diet.
- Get regular vaccinations (e.g., flu, pneumonia) to prevent respiratory infections.
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