Ondastat
Generic Name
Ondansetron
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ondastat 8 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Ondansetron is an antiemetic used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and surgery.
Uses & Indications
Dosage
Adults
Chemotherapy-induced nausea and vomiting: 8-24 mg orally or intravenously, depending on emetogenicity. Post-operative nausea and vomiting: 16 mg orally one hour before anesthesia, or 4 mg IV/IM at induction.
Elderly
No general dose adjustment required, but caution in patients over 75 years due to risk of QT prolongation.
Renal_impairment
No dosage adjustment needed for patients with renal impairment.
How to Take
Oral tablets can be taken with or without food. Oral solution can be measured with a dosing syringe. Injections are administered intravenously or intramuscularly by a healthcare professional.
Mechanism of Action
It works by blocking serotonin, a natural substance in the body that can cause nausea and vomiting.
Pharmacokinetics
Onset
Approximately 30 minutes (oral), a few minutes (IV).
Excretion
About 5% is excreted unchanged in urine, with the remainder excreted as metabolites via urine and feces.
Half life
Approximately 3-6 hours in adults, longer in elderly and renally/hepatically impaired patients.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are reached within 1.5 hours.
Metabolism
Extensively metabolized in the liver by multiple cytochrome P450 enzymes (CYP1A2, CYP2D6, CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to ondansetron or any component of the formulation.
- Concomitant use with apomorphine.
Drug Interactions
Tramadol
Increased risk of serotonin syndrome.
Apomorphine
Concomitant use is contraindicated due to severe hypotension and loss of consciousness.
QT-prolonging drugs
Increased risk of QT prolongation and Torsade de Pointes.
Phenytoin, Carbamazepine, Rifampicin
May decrease ondansetron levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose may cause visual disturbances, severe constipation, hypotension, and vasovagal episodes. Management includes symptomatic and supportive treatment, including ECG monitoring.
Pregnancy & Lactation
Pregnancy Category B. Studies in pregnant animals have not shown a risk to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use during lactation should be with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, specific expiry date mentioned on the packaging.
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available, patent expired
WHO Essential Medicine
YesClinical Trials
Ondansetron has been extensively studied in numerous clinical trials demonstrating its efficacy and safety for CINV, RINV, and PONV.
Lab Monitoring
- ECG monitoring in patients with cardiac risk factors or those receiving other QT-prolonging drugs.
- Liver function tests for patients on prolonged therapy.
Doctor Notes
- Monitor ECG in patients with underlying cardiac conditions or those taking other QT-prolonging medications.
- Not effective for all causes of nausea and vomiting; consider underlying etiology.
- Use with caution in patients with hepatic impairment, as clearance may be reduced.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Report any unusual side effects to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Ondansetron may cause dizziness or drowsiness. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that ondansetron therapy does not affect their ability to engage in such activities.
Lifestyle Advice
- Stay hydrated, especially during chemotherapy or radiation therapy.
- Avoid foods and smells that trigger nausea.
- Rest adequately.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.