Onefix DS
Generic Name
Cefixime
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| onefix ds 200 mg suspension | ৳ 280.00 | N/A |
Description
Overview of the medicine
Onefix DS is an oral third-generation cephalosporin antibiotic (Cefixime) used to treat various bacterial infections, primarily in children. It comes as a powder that needs to be reconstituted with water to form an oral suspension.
Uses & Indications
Dosage
Adults
Though Onefix DS is primarily for children, the adult dose for Cefixime is typically 200 mg to 400 mg daily, given as a single dose or in two divided doses.
Children
Recommended dose is 8 mg/kg/day, administered as a single dose or in two divided doses every 12 hours. For children weighing over 50 kg or older than 12 years, the adult dose is recommended.
Renal_impairment
Dosage adjustment is necessary for patients with severe renal impairment (creatinine clearance < 30 ml/min). The dose should be reduced to 4 mg/kg/day.
How to Take
Onefix DS is an oral suspension. Reconstitute the powder with boiled and cooled water as per instructions on the label. Shake the bottle well before each use. Can be taken with or without food. Complete the full course of treatment as prescribed by the doctor.
Mechanism of Action
Cefixime exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the cross-linking of peptidoglycan chains that are essential for bacterial cell wall strength and rigidity. This leads to cell lysis and bacterial death.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved 2-6 hours after administration.
Excretion
Primarily excreted by the kidneys (about 50% of the absorbed dose is excreted unchanged in urine within 24 hours), and also through biliary excretion.
Half life
The plasma half-life is typically 3-4 hours.
Absorption
Approximately 40-50% orally absorbed. Absorption is not significantly altered by food.
Metabolism
Cefixime is not extensively metabolized in the body; a small amount undergoes metabolism in the gut.
Side Effects
Contraindications
- Hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reaction to any penicillin antibiotic.
Drug Interactions
0
Anticoagulants (e.g., Warfarin): May increase prothrombin time, potentially leading to increased bleeding risk. Close monitoring of coagulation parameters is recommended.
1
Carbamazepine: Concomitant use may increase carbamazepine plasma concentrations.
2
Oral Contraceptives: Cefixime may reduce the efficacy of oral contraceptives in some cases.
3
Probenecid: May increase cefixime plasma levels by reducing renal excretion.
Storage
Store the unreconstituted powder below 30°C, protected from light and moisture. Keep out of reach of children. Store the reconstituted suspension in a refrigerator (2-8°C) and use within 7 days. Do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administering to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reaction to any penicillin antibiotic.
Drug Interactions
0
Anticoagulants (e.g., Warfarin): May increase prothrombin time, potentially leading to increased bleeding risk. Close monitoring of coagulation parameters is recommended.
1
Carbamazepine: Concomitant use may increase carbamazepine plasma concentrations.
2
Oral Contraceptives: Cefixime may reduce the efficacy of oral contraceptives in some cases.
3
Probenecid: May increase cefixime plasma levels by reducing renal excretion.
Storage
Store the unreconstituted powder below 30°C, protected from light and moisture. Keep out of reach of children. Store the reconstituted suspension in a refrigerator (2-8°C) and use within 7 days. Do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administering to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 years for the unreconstituted powder. 7 days for the reconstituted suspension when stored in a refrigerator.
Availability
Pharmacies nationwide in Bangladesh
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Cefixime has been extensively studied in various clinical trials for its efficacy and safety in treating a wide range of bacterial infections in both adults and pediatric populations.
Lab Monitoring
- Complete Blood Count (CBC) and liver/renal function tests may be monitored during prolonged therapy.
- Coagulation parameters should be monitored in patients receiving anticoagulants.
Doctor Notes
- Educate parents/caregivers on proper reconstitution and administration techniques for oral suspension.
- Emphasize the importance of completing the entire prescribed course to minimize resistance.
- Monitor for signs of hypersensitivity reactions, especially in patients with a history of penicillin allergy.
Patient Guidelines
- Complete the full course of antibiotics as prescribed, even if symptoms improve, to prevent the development of antibiotic resistance.
- Shake the reconstituted suspension well before each use.
- Use an accurate measuring device to ensure correct dosing, especially for children.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Cefixime may cause dizziness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how the drug affects them.
Lifestyle Advice
- Maintain adequate hydration by drinking plenty of fluids.
- Avoid self-medication and consult a doctor for proper diagnosis and treatment.
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