Onelock
Generic Name
Esomeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| onelock 20 mg capsule | ৳ 6.00 | ৳ 60.00 |
| onelock 40 mg capsule | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Esomeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. It is used to treat conditions such as gastroesophageal reflux disease (GERD), stomach ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
GERD: 20-40 mg once daily for 4-8 weeks. H. pylori: 20 mg twice daily for 10 days (with antibiotics). Zollinger-Ellison Syndrome: 40-80 mg twice daily.
Elderly
Generally, no dose adjustment is required for elderly patients.
Renal_impairment
No dose adjustment is necessary for patients with impaired renal function.
How to Take
Take at least one hour before a meal, swallow the capsule whole. Do not chew or crush.
Mechanism of Action
Irreversibly inhibits the H+/K+-ATPase proton pump in gastric parietal cells, thereby reducing gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour.
Excretion
Mainly renal (approx. 80%) and fecal (approx. 20%).
Half life
Approximately 1-1.5 hours.
Absorption
Rapidly absorbed. Bioavailability increases with repeated dosing.
Metabolism
Extensively hepatic via CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Warfarin
May increase INR and bleeding risk.
Clopidogrel
May decrease the antiplatelet effect of clopidogrel.
Methotrexate
May increase methotrexate levels and toxicity.
Atazanavir/Nelfinavir
May significantly decrease the plasma levels of these antiretrovirals.
Storage
Store below 30°C, in a dry place, protected from light and moisture.
Overdose
Treatment of overdose is symptomatic and supportive. Esomeprazole is extensively protein bound and not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit justifies the potential risk to the fetus. It is unknown if esomeprazole is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent expired for generic versions
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials support its efficacy and safety in various acid-related disorders. Studies have shown superior efficacy over omeprazole in healing erosive esophagitis.
Doctor Notes
- Consider the lowest effective dose for the shortest duration necessary.
- Monitor patients on long-term therapy for potential adverse effects, including bone density and vitamin B12 levels.
- Advise patients on lifestyle modifications to complement drug therapy.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking Onelock suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule.
Driving Precautions
Esomeprazole generally does not impair ability to drive or operate machinery. However, if dizziness or visual disturbances occur, caution should be exercised.
Lifestyle Advice
- Elevate the head of your bed during sleep.
- Eat smaller, more frequent meals.
- Avoid late-night meals and trigger foods (e.g., spicy, fatty foods, caffeine).
- Maintain a healthy weight.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.