Onvicon
Generic Name
Amoxicillin
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| onvicon 500 mg suspension | ৳ 150.00 | N/A |
Description
Overview of the medicine
Onvicon 500 mg Suspension contains Amoxicillin, a penicillin-type antibiotic used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
250-500 mg every 8 hours, or 500-875 mg every 12 hours, depending on the severity and type of infection. For severe infections, up to 1 gram every 8 hours.
Elderly
No specific dosage adjustment needed for elderly patients with normal renal function. Dosage adjustment may be required in cases of significant renal impairment.
Renal_impairment
For creatinine clearance 10-30 mL/min, 250-500 mg every 12 hours. For creatinine clearance <10 mL/min, 250-500 mg every 24 hours. Hemodialysis patients: 250-500 mg every 24 hours, with an additional dose during and at the end of dialysis.
How to Take
Shake the bottle well before each use. Measure the prescribed dose using the provided measuring spoon or cup. Can be taken with or without food. Complete the full course of treatment as prescribed by the doctor, even if symptoms improve.
Mechanism of Action
Amoxicillin works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located on the inner bacterial cell membrane, which prevents the cross-linking of peptidoglycan polymers, essential for bacterial cell wall strength and integrity. This leads to weakened bacterial cell walls and eventual cell lysis and death.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Primarily excreted unchanged by the kidneys via glomerular filtration and tubular secretion. Approximately 60-70% of a dose is excreted in the urine within 6 hours.
Half life
Approximately 1-1.5 hours in adults with normal renal function.
Absorption
Rapidly and well absorbed from the gastrointestinal tract, with bioavailability of approximately 70-90%. Peak plasma concentrations are reached within 1-2 hours after oral administration.
Metabolism
Minimal hepatic metabolism; about 10-25% is metabolized to inactive penicilloic acid.
Side Effects
Contraindications
- Known hypersensitivity to penicillin antibiotics or to any component of the formulation.
- History of severe allergic reaction (e.g., anaphylaxis) to any beta-lactam antibiotic (e.g., cephalosporins, carbapenems).
Drug Interactions
Probenecid
Increases and prolongs plasma levels of amoxicillin by competing for renal tubular secretion.
Allopurinol
Concomitant use with amoxicillin may increase the incidence of skin rash.
Methotrexate
Amoxicillin may reduce the renal excretion of methotrexate, increasing its toxicity.
Warfarin and other oral anticoagulants
May increase the anticoagulant effect, requiring closer monitoring of INR.
Storage
Store dry powder below 30°C, protected from light and moisture. Once reconstituted, store the suspension in a refrigerator (2-8°C) and discard any unused portion after 7 to 14 days, as per specific product instructions.
Overdose
Symptoms of overdose may include gastrointestinal disturbances such as nausea, vomiting, and diarrhea, and fluid and electrolyte imbalance. In rare cases, renal failure and convulsions may occur. Treatment is symptomatic and supportive. Hemodialysis can remove amoxicillin from circulation.
Pregnancy & Lactation
Amoxicillin is generally considered safe during pregnancy (Pregnancy Category B) and lactation. However, it should only be used if clearly needed and under medical supervision. Small amounts are excreted in breast milk, which may lead to sensitization or gastrointestinal disturbances in the infant.
Side Effects
Contraindications
- Known hypersensitivity to penicillin antibiotics or to any component of the formulation.
- History of severe allergic reaction (e.g., anaphylaxis) to any beta-lactam antibiotic (e.g., cephalosporins, carbapenems).
Drug Interactions
Probenecid
Increases and prolongs plasma levels of amoxicillin by competing for renal tubular secretion.
Allopurinol
Concomitant use with amoxicillin may increase the incidence of skin rash.
Methotrexate
Amoxicillin may reduce the renal excretion of methotrexate, increasing its toxicity.
Warfarin and other oral anticoagulants
May increase the anticoagulant effect, requiring closer monitoring of INR.
Storage
Store dry powder below 30°C, protected from light and moisture. Once reconstituted, store the suspension in a refrigerator (2-8°C) and discard any unused portion after 7 to 14 days, as per specific product instructions.
Overdose
Symptoms of overdose may include gastrointestinal disturbances such as nausea, vomiting, and diarrhea, and fluid and electrolyte imbalance. In rare cases, renal failure and convulsions may occur. Treatment is symptomatic and supportive. Hemodialysis can remove amoxicillin from circulation.
Pregnancy & Lactation
Amoxicillin is generally considered safe during pregnancy (Pregnancy Category B) and lactation. However, it should only be used if clearly needed and under medical supervision. Small amounts are excreted in breast milk, which may lead to sensitization or gastrointestinal disturbances in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months (unreconstituted powder). 7-14 days (reconstituted suspension) when stored in a refrigerator.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory bodies (e.g., DGDA)
Patent Status
Generic drug, patent expired globally
WHO Essential Medicine
YesClinical Trials
Amoxicillin has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections, leading to its widespread use and inclusion in essential medicines lists worldwide.
Lab Monitoring
- Renal function tests (for prolonged therapy or in patients with pre-existing renal impairment)
- Liver function tests (rarely, in patients with pre-existing liver disease or long-term therapy)
- Complete blood count (CBC) (for prolonged therapy)
Doctor Notes
- Ascertain penicillin allergy history before prescribing.
- Advise patients to complete the full course of treatment.
- Monitor for signs of superinfection or C. difficile infection, especially with prolonged use.
Patient Guidelines
- Always complete the full course of treatment, even if you feel better, to prevent the return of infection and development of antibiotic resistance.
- Shake the suspension well before each use.
- Store the reconstituted suspension in the refrigerator as directed.
- Report any severe or persistent side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Amoxicillin is generally not expected to impair the ability to drive or operate machinery. However, if side effects such as dizziness or headache occur, caution should be exercised.
Lifestyle Advice
- Maintain adequate hydration by drinking plenty of fluids.
- Ensure proper hygiene to prevent the spread of infection.
- Avoid sharing this medication with others.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.