Opiren
Generic Name
Rabeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| opiren 30 mg capsule | ৳ 9.00 | N/A |
Description
Overview of the medicine
Opiren 30 mg capsule contains Rabeprazole, which is a proton pump inhibitor (PPI) used to treat conditions where there is too much acid in the stomach. It works by irreversibly blocking the proton pump in the gastric parietal cells, thereby reducing gastric acid secretion.
Uses & Indications
Dosage
Adults
The usual adult dose for gastroesophageal reflux disease (GERD) is 20 mg once daily. For the 30 mg strength, it may be used for severe erosive esophagitis, Zollinger-Ellison syndrome, or when a higher dose is deemed necessary by a physician. For Zollinger-Ellison syndrome, the initial dose is typically 60 mg once daily, adjusted as needed. For H. pylori eradication, a specific 30 mg dose might be part of a combination regimen.
Elderly
No dosage adjustment is generally required for elderly patients, but caution is advised.
Renal_impairment
No dosage adjustment is necessary for patients with renal impairment.
How to Take
Take the capsule orally, preferably in the morning before breakfast. Swallow the capsule whole with water; do not chew or crush it.
Mechanism of Action
Rabeprazole belongs to a class of antisecretory compounds, the substituted benzimidazoles, that do not exhibit anticholinergic or H2-histamine antagonistic properties, but suppress gastric acid secretion by inhibiting the gastric H+/K+-ATPase (the proton pump) at the secretory surface of the gastric parietal cell. This effect is dose-related and leads to inhibition of both basal and stimulated acid secretion.
Pharmacokinetics
Onset
Within 1 hour of administration.
Excretion
Approximately 90% of a dose is excreted in the urine, predominantly as metabolites, and 10% is excreted in the feces.
Half life
Plasma elimination half-life is approximately 1-2 hours in healthy subjects, independent of dose. However, the duration of acid suppression is much longer due to irreversible binding to the proton pump.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations occurring approximately 2-3.5 hours post-dose. Absolute bioavailability is approximately 52% due to presystemic metabolism. Food and time of administration do not significantly affect absorption.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 (CYP) isoenzymes CYP2C19 and CYP3A4. Its main metabolites are thioether and sulfone.
Side Effects
Contraindications
- Hypersensitivity to rabeprazole, substituted benzimidazoles, or any component of the formulation.
- Not recommended for immediate relief of heartburn.
Drug Interactions
Digoxin
May increase digoxin absorption and plasma concentrations.
Warfarin
Increased INR and prothrombin time; monitor closely.
Clopidogrel
Reduced antiplatelet effect of clopidogrel. Avoid concomitant use.
Methotrexate
Increased and prolonged plasma concentrations of methotrexate; monitor for toxicity.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
There is limited experience with overdosage. Symptoms may include drowsiness, headache, nausea, vomiting, and diarrhea. In the event of overdose, treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown evidence of impaired fertility or harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Rabeprazole and/or its metabolites are excreted in breast milk in rats, but it is not known whether rabeprazole is excreted in human milk. Caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to rabeprazole, substituted benzimidazoles, or any component of the formulation.
- Not recommended for immediate relief of heartburn.
Drug Interactions
Digoxin
May increase digoxin absorption and plasma concentrations.
Warfarin
Increased INR and prothrombin time; monitor closely.
Clopidogrel
Reduced antiplatelet effect of clopidogrel. Avoid concomitant use.
Methotrexate
Increased and prolonged plasma concentrations of methotrexate; monitor for toxicity.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
There is limited experience with overdosage. Symptoms may include drowsiness, headache, nausea, vomiting, and diarrhea. In the event of overdose, treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown evidence of impaired fertility or harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Rabeprazole and/or its metabolites are excreted in breast milk in rats, but it is not known whether rabeprazole is excreted in human milk. Caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved (various national regulatory bodies)
Patent Status
Off-patent in many regions
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of rabeprazole in treating various acid-related disorders. Ongoing research continues to evaluate its long-term safety and potential new applications.
Lab Monitoring
- Magnesium levels (especially with long-term use, concomitant diuretics, or digoxin)
- Liver function tests (in patients with severe hepatic impairment)
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration necessary.
- Re-evaluate the need for continued PPI therapy periodically.
- Counsel patients on potential long-term risks, especially for those on concomitant medications that can exacerbate risks (e.g., diuretics with hypomagnesemia).
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not chew, crush, or break the capsule; swallow it whole.
- Report any severe or persistent side effects to your doctor.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Rabeprazole is generally not expected to affect the ability to drive or operate machinery. However, some adverse reactions such as dizziness or somnolence may occur, which could impair the ability to drive or operate machinery. If affected, avoid such activities.
Lifestyle Advice
- Avoid trigger foods and beverages (e.g., spicy foods, fatty foods, caffeine, alcohol) that worsen acid reflux.
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating; wait at least 2-3 hours.
- Elevate the head of your bed to reduce nighttime reflux.
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