Optagel-2
Generic Name
Sodium Hyaluronate Viscoelastic Solution
Manufacturer
Generic Pharmaceutical Company
Country
Varies by manufacturer
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| optagel 2 viscoelastic solution | ৳ 120.45 | N/A |
Description
Overview of the medicine
Optagel-2 viscoelastic solution is a sterile, non-pyrogenic, transparent solution of sodium hyaluronate, designed for use as a surgical aid in various ophthalmic procedures. It helps to maintain surgical space, protect delicate intraocular tissues, and facilitate manipulation during surgery like cataract extraction and intraocular lens implantation. Its high viscosity and elasticity contribute to a stable anterior chamber and reduce trauma to the corneal endothelium and other structures.
Uses & Indications
Dosage
Adults
Administered intraocularly by a surgeon as needed during ophthalmic surgery. The volume depends on the procedure and surgeon's discretion, typically 0.5 mL to 2.0 mL.
Elderly
No specific dosage adjustment required; same as adults.
Renal_impairment
Not applicable, as it is not systemically absorbed.
How to Take
For intraocular use only. Administered by a trained ophthalmic surgeon into the anterior chamber or other intraocular spaces during surgery using a sterile cannula.
Mechanism of Action
Sodium hyaluronate is a naturally occurring glycosaminoglycan that provides viscosity and elasticity to the solution. When introduced into the eye during surgery, it acts as a space maintainer, separating tissues and protecting the delicate corneal endothelium and other intraocular structures from mechanical trauma and irrigation solution turbulence. Its pseudoplastic nature allows it to be easily injected and manipulated, yet it regains its viscosity at rest, providing stable surgical conditions.
Pharmacokinetics
Onset
Immediate upon intraocular injection.
Excretion
Primarily cleared from the anterior chamber via the trabecular meshwork and uveoscleral outflow pathways, then metabolized locally.
Half life
Approximately 24-48 hours within the anterior chamber, depending on molecular weight and ocular turnover.
Absorption
Intraocularly administered sodium hyaluronate is not absorbed systemically to a significant extent. It remains primarily within the anterior chamber and is gradually cleared.
Metabolism
Broken down by hyaluronidase enzymes present in ocular tissues.
Side Effects
Contraindications
- •Hypersensitivity to sodium hyaluronate or any component of the solution.
- •Known severe allergies to bacterial proteins (if derived from bacterial fermentation).
Drug Interactions
None significant
No known systemic drug interactions due to minimal systemic absorption. Local interactions with other ophthalmic agents used during surgery are not typically problematic but should be considered by the surgeon.
Storage
Store at controlled room temperature (15-30°C) or refrigerated (2-8°C) as per manufacturer's instructions. Protect from freezing and excessive heat. Do not resterilize.
Overdose
Intraocular overdose is unlikely in a surgical setting. If an excessive amount is used, it may lead to temporary increase in intraocular pressure (IOP), which usually resolves spontaneously or can be managed by irrigation.
Pregnancy & Lactation
Not studied. As a locally applied surgical aid with minimal systemic absorption, risks are considered low. Use only if clearly needed during ophthalmic surgery.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years when stored properly.
Availability
Hospitals, surgical centers, specialized ophthalmic clinics.
Approval Status
Approved by major regulatory bodies for ophthalmic use.
Patent Status
Likely generic or off-patent for Sodium Hyaluronate. Specific formulation might have some patents.
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