Oral-Z
Generic Name
Zinc Sulfate Monohydrate
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| oral z 10 mg syrup | ৳ 55.00 | N/A |
Description
Overview of the medicine
Oral-Z 10 mg Syrup contains Zinc Sulfate Monohydrate, an essential trace element vital for proper growth, immune function, protein synthesis, and wound healing. It is commonly used to treat and prevent zinc deficiency and as an adjunct in the management of acute diarrhea.
Uses & Indications
Dosage
Adults
Zinc deficiency: 20-40 mg elemental zinc daily, in divided doses, or as directed by physician. Diarrhea: As per WHO guidelines, often higher short-term doses.
Elderly
No specific dosage adjustment required for elderly patients unless renal impairment is present. Follow adult dosage.
Renal_impairment
Use with caution in severe renal impairment. Physician consultation recommended.
How to Take
Oral-Z Syrup should be taken orally. It can be taken with or without food, but taking it with food may help reduce gastrointestinal upset. For children, it can be mixed with a small amount of water or breast milk.
Mechanism of Action
Zinc acts as a cofactor for over 300 enzymes involved in various metabolic processes. It plays a crucial role in immune system function, cell division, DNA synthesis, and protein synthesis. In diarrhea, zinc supplementation has been shown to reduce the severity and duration of episodes and prevent future occurrences.
Pharmacokinetics
Onset
Therapeutic effects for deficiency or diarrhea management are observed over days to weeks.
Excretion
Mainly excreted via feces (approximately 90%), with smaller amounts excreted in urine and sweat.
Half life
Plasma half-life is approximately 2.8 hours, but whole-body turnover can be several days to months due to redistribution.
Absorption
Approximately 20-40% of dietary zinc is absorbed, primarily in the small intestine. Absorption can be influenced by diet (e.g., phytates, fiber decrease absorption) and the body's zinc status.
Metabolism
Zinc is not metabolized in the traditional sense; it's a mineral that participates in metabolic reactions.
Side Effects
Contraindications
- Hypersensitivity to zinc salts or any component of the formulation.
- Patients with copper deficiency (high doses of zinc can induce copper deficiency).
Drug Interactions
Penicillamine
Zinc may decrease the absorption and effectiveness of penicillamine.
Iron supplements
High doses of zinc can interfere with iron absorption. Administer at separate times.
Copper supplements
High doses of zinc can interfere with copper absorption and may induce copper deficiency. Avoid concomitant high-dose use.
Tetracyclines & Quinolones
Zinc can reduce the absorption of these antibiotics. Take zinc at least 2 hours before or 4-6 hours after these antibiotics.
Storage
Store in a cool, dry place, below 30°C. Protect from light. Keep out of reach of children.
Overdose
Symptoms of acute zinc overdose include nausea, vomiting, abdominal pain, diarrhea, and gastric erosion. Chronic overdose can lead to copper deficiency, anemia, and neurological problems. Treatment involves supportive care and discontinuation of zinc. Do not induce vomiting without medical advice.
Pregnancy & Lactation
Zinc is essential during pregnancy and lactation. Oral-Z 10 mg Syrup can be used during pregnancy and breastfeeding at recommended dosages to ensure adequate zinc intake. Consult a doctor for appropriate dosage.
Side Effects
Contraindications
- Hypersensitivity to zinc salts or any component of the formulation.
- Patients with copper deficiency (high doses of zinc can induce copper deficiency).
Drug Interactions
Penicillamine
Zinc may decrease the absorption and effectiveness of penicillamine.
Iron supplements
High doses of zinc can interfere with iron absorption. Administer at separate times.
Copper supplements
High doses of zinc can interfere with copper absorption and may induce copper deficiency. Avoid concomitant high-dose use.
Tetracyclines & Quinolones
Zinc can reduce the absorption of these antibiotics. Take zinc at least 2 hours before or 4-6 hours after these antibiotics.
Storage
Store in a cool, dry place, below 30°C. Protect from light. Keep out of reach of children.
Overdose
Symptoms of acute zinc overdose include nausea, vomiting, abdominal pain, diarrhea, and gastric erosion. Chronic overdose can lead to copper deficiency, anemia, and neurological problems. Treatment involves supportive care and discontinuation of zinc. Do not induce vomiting without medical advice.
Pregnancy & Lactation
Zinc is essential during pregnancy and lactation. Oral-Z 10 mg Syrup can be used during pregnancy and breastfeeding at recommended dosages to ensure adequate zinc intake. Consult a doctor for appropriate dosage.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies, drugstores
Approval Status
Approved (local regulatory authority)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials support the efficacy of zinc supplementation in reducing the duration and severity of acute diarrhea in children and treating zinc deficiency.
Lab Monitoring
- Serum zinc levels (if deficiency is suspected or for monitoring therapy)
- Serum copper levels (for long-term high-dose zinc therapy)
Doctor Notes
- Advise parents on the importance of completing the full 10-14 day course of zinc for diarrhea, even if symptoms improve earlier.
- Counsel patients on potential drug interactions, especially with antibiotics and iron supplements.
- Consider assessing dietary intake of zinc and copper for patients on long-term therapy.
Patient Guidelines
- Follow the prescribed dosage and duration, especially for diarrhea management.
- Do not exceed the recommended dose without medical advice.
- Inform your doctor about all other medications you are taking.
- Take with food if gastrointestinal upset occurs.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Oral-Z 10 mg Syrup is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in zinc-containing foods like meat, shellfish, legumes, nuts, and dairy.
- Ensure adequate hydration during diarrhea episodes.
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