Orbidex-01
Generic Name
Moxifloxacin Hydrochloride + Dexamethasone Sodium Phosphate
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| orbidex 01 eye drop | ৳ 70.00 | N/A |
Description
Overview of the medicine
Orbidex-01 Eye Drop is a sterile ophthalmic solution containing a broad-spectrum fluoroquinolone antibiotic (Moxifloxacin) and a potent corticosteroid (Dexamethasone) used to treat bacterial infections of the eye and reduce associated inflammation. It is effective against a wide range of gram-positive and gram-negative bacteria.
Uses & Indications
Dosage
Adults
Instill 1 drop into the affected eye(s) 2-4 times daily for up to 7 days, or as directed by a physician. Shake well before use.
Elderly
No special dosage adjustment required for elderly patients.
Renal_impairment
No dosage adjustment required for renal impairment as systemic absorption is minimal.
How to Take
For ophthalmic use only. Tilt head back, pull down the lower eyelid to form a pocket, and instill the drop. Close eye gently. Avoid touching the dropper tip to the eye or any other surface to prevent contamination. If using other eye drops, wait at least 5 minutes between applications.
Mechanism of Action
Moxifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death. Dexamethasone is a potent synthetic corticosteroid that suppresses inflammation by inhibiting phospholipase A2 and reducing the release of inflammatory mediators.
Pharmacokinetics
Onset
Antibacterial effect typically within hours; anti-inflammatory effect within days.
Excretion
Excreted primarily through urine and feces for systemically absorbed components.
Half life
Systemic half-life of moxifloxacin is approximately 11-15 hours; topical ocular half-life is shorter due to local elimination.
Absorption
Minimal systemic absorption after topical ophthalmic administration. Peak concentrations in aqueous humor are achieved within 0.5-2 hours.
Metabolism
Mainly hepatic metabolism for systemically absorbed moxifloxacin; minimal for topical ophthalmic use. Dexamethasone is also hepatically metabolized.
Side Effects
Contraindications
- Hypersensitivity to Moxifloxacin, Dexamethasone, or any components of the formulation.
- Viral diseases of the cornea and conjunctiva (e.g., herpes simplex keratitis).
- Mycobacterial eye infection.
- Fungal infections of ocular structures.
Drug Interactions
Systemic corticosteroids
Increased risk of systemic side effects if significant absorption occurs (rare with eye drops).
Other topical ophthalmic medications
Allow at least 5 minutes between applications.
Storage
Store at room temperature (below 30°C). Protect from light and moisture. Keep out of reach of children.
Overdose
Topical ophthalmic overdose is unlikely to cause systemic toxicity due to limited absorption. If accidental ingestion occurs, symptomatic and supportive measures are recommended.
Pregnancy & Lactation
Use in pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. Dexamethasone and Moxifloxacin are excreted in breast milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to Moxifloxacin, Dexamethasone, or any components of the formulation.
- Viral diseases of the cornea and conjunctiva (e.g., herpes simplex keratitis).
- Mycobacterial eye infection.
- Fungal infections of ocular structures.
Drug Interactions
Systemic corticosteroids
Increased risk of systemic side effects if significant absorption occurs (rare with eye drops).
Other topical ophthalmic medications
Allow at least 5 minutes between applications.
Storage
Store at room temperature (below 30°C). Protect from light and moisture. Keep out of reach of children.
Overdose
Topical ophthalmic overdose is unlikely to cause systemic toxicity due to limited absorption. If accidental ingestion occurs, symptomatic and supportive measures are recommended.
Pregnancy & Lactation
Use in pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. Dexamethasone and Moxifloxacin are excreted in breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months (unopened). Use within 28 days of opening.
Availability
Available in retail pharmacies, hospitals, and clinics
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Brand specific patent may apply; generic components off-patent
Clinical Trials
Clinical trials demonstrated efficacy and safety in treating bacterial ocular infections with associated inflammation. Studies confirmed superior outcomes compared to monotherapy with either antibiotic or steroid alone.
Lab Monitoring
- Regular intraocular pressure (IOP) monitoring during prolonged use (more than 10 days) of corticosteroid-containing preparations.
Doctor Notes
- Advise patients to report any vision changes, new onset of pain, or worsening of symptoms immediately.
- Emphasize the importance of completing the full course to prevent recurrence and resistance.
Patient Guidelines
- Do not wear contact lenses during treatment for eye infection.
- Wash hands thoroughly before and after applying the eye drop.
- Complete the full course of treatment as prescribed, even if symptoms improve.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.
Driving Precautions
May cause temporary blurred vision or discomfort. Do not drive or operate machinery until vision is clear.
Lifestyle Advice
- Avoid rubbing your eyes.
- Maintain good ocular hygiene.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.