Orcenac
Generic Name
orcenac-100-mg-tablet
Manufacturer
MediCare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| orcenac 100 mg tablet | ৳ 4.02 | ৳ 40.20 |
Description
Overview of the medicine
Orcenac 100 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and fever. It is prescribed for conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Uses & Indications
Dosage
Adults
100 mg twice daily, preferably after food. Maximum daily dose should not exceed 200 mg.
Elderly
A lower initial dose may be considered, and patients should be monitored for adverse effects.
Renal_impairment
Dose adjustment may be necessary. Avoid use in severe renal impairment.
How to Take
Take Orcenac 100 mg Tablet orally with a glass of water, preferably during or immediately after meals to minimize gastrointestinal upset.
Mechanism of Action
Orcenac works by inhibiting the synthesis of prostaglandins, which are chemicals in the body that contribute to pain, inflammation, and fever. It primarily acts by blocking the cyclooxygenase (COX-1 and COX-2) enzymes.
Pharmacokinetics
Onset
Onset of action typically occurs within 30-60 minutes.
Excretion
Excreted mainly through the kidneys (urine), with some fecal excretion.
Half life
The elimination half-life is approximately 2-4 hours.
Absorption
Rapidly absorbed after oral administration, reaching peak plasma concentrations within 1-2 hours.
Metabolism
Primarily metabolized in the liver, largely via cytochrome P450 (CYP) enzymes.
Side Effects
Contraindications
- Hypersensitivity to Orcenac or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- History of aspirin-induced asthma, urticaria, or allergic-type reactions
Drug Interactions
Lithium
Increased plasma lithium levels and toxicity.
Methotrexate
Increased methotrexate toxicity.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered if ingestion was recent.
Pregnancy & Lactation
Avoid use in the third trimester of pregnancy due to potential fetal harm and prolonged labor. Use with caution in the first and second trimesters only if the potential benefit outweighs the risk. Not recommended during breastfeeding due to potential excretion in breast milk.
Side Effects
Contraindications
- Hypersensitivity to Orcenac or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- History of aspirin-induced asthma, urticaria, or allergic-type reactions
Drug Interactions
Lithium
Increased plasma lithium levels and toxicity.
Methotrexate
Increased methotrexate toxicity.
Diuretics and ACE inhibitors
Reduced antihypertensive effect and increased risk of renal impairment.
Warfarin and other anticoagulants
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, and gastrointestinal bleeding. Management involves symptomatic and supportive care. Gastric lavage and activated charcoal may be considered if ingestion was recent.
Pregnancy & Lactation
Avoid use in the third trimester of pregnancy due to potential fetal harm and prolonged labor. Use with caution in the first and second trimesters only if the potential benefit outweighs the risk. Not recommended during breastfeeding due to potential excretion in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent pending
Clinical Trials
Orcenac has undergone Phase III clinical trials demonstrating its efficacy and safety in patients with various inflammatory conditions. Post-marketing surveillance data is continuously collected.
Lab Monitoring
- Regular monitoring of renal function (creatinine, BUN)
- Liver function tests (ALT, AST)
- Complete Blood Count (CBC) for long-term therapy
Doctor Notes
- Advise patients on the importance of taking the medication with food to reduce GI side effects.
- Monitor renal and hepatic function, especially in elderly patients or those with pre-existing conditions.
- Educate patients about the signs of GI bleeding and cardiovascular events.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not exceed the recommended dose or duration of treatment.
- Report any unusual symptoms or adverse effects to your doctor immediately.
- Avoid taking other NSAIDs concurrently without consulting your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a forgotten dose.
Driving Precautions
Orcenac may cause dizziness, drowsiness, or visual disturbances. Patients should be cautioned against driving or operating machinery if they experience these effects.
Lifestyle Advice
- Avoid excessive alcohol consumption while taking this medication, as it may increase the risk of stomach irritation.
- Maintain adequate hydration, especially if you have renal impairment.
- Discuss with your doctor about potential dietary modifications.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.