Orcerin
Generic Name
Diacerein
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| orcerin 750 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Orcerin (Diacerein) is a slow-acting medicine used for the symptomatic treatment of osteoarthritis. It helps to reduce pain and inflammation and slow down cartilage degradation. Note: Diacerein is typically available as 50 mg formulations; a 750 mg strength is not standard or commonly found.
Uses & Indications
Dosage
Adults
Initial phase: 50 mg once daily for 2-4 weeks. Maintenance: 50 mg twice daily, taken with food.
Elderly
No specific dosage adjustment needed unless renal impairment is present. Start with lower dose if concerns.
Renal_impairment
Reduce dosage in patients with severe renal impairment (creatinine clearance < 30 mL/min). Consider 50 mg once daily.
How to Take
Take with food to increase absorption and reduce gastrointestinal side effects. Swallow the tablet whole with a glass of water.
Mechanism of Action
Diacerein inhibits the production and activity of interleukin-1 beta (IL-1β), a key cytokine involved in cartilage degradation and inflammation in osteoarthritis.
Pharmacokinetics
Onset
Slow onset of action, symptomatic relief typically takes 2-4 weeks.
Excretion
Mainly excreted via the kidneys.
Half life
Rhein has a plasma half-life of approximately 4-8 hours.
Absorption
Well absorbed orally, extensively metabolized to the active metabolite rhein.
Metabolism
Diacerein is a prodrug, rapidly metabolized to its active form, rhein, primarily in the liver.
Side Effects
Contraindications
- Hypersensitivity to Diacerein or any of its components
- Inflammatory Bowel Disease (Crohn's disease, ulcerative colitis)
- Severe hepatic disease
Drug Interactions
Antacids
May reduce the absorption of Diacerein; take at least 1-2 hours apart.
Laxatives
Concomitant use may increase the risk of diarrhea.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to severe diarrhea and gastrointestinal disturbances. Management is symptomatic and supportive, including fluid and electrolyte replacement.
Pregnancy & Lactation
Not recommended during pregnancy and lactation due to insufficient safety data. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date
Availability
Available in pharmacies
Approval Status
Approved in many countries for osteoarthritis
Patent Status
Off-patent
Clinical Trials
Numerous clinical trials have been conducted to evaluate the efficacy and safety of Diacerein in the management of osteoarthritis, showing beneficial effects on symptoms and joint structure.
Lab Monitoring
- Liver function tests (baseline and periodic monitoring, especially in patients at risk of liver disease)
- Renal function tests (for dose adjustment in renal impairment)
Doctor Notes
- Emphasize the slow onset of action; may require co-administration with rapid-acting analgesics initially.
- Advise patients on potential gastrointestinal side effects, especially diarrhea, and the need for liver function monitoring.
- Note: Diacerein is typically available as 50 mg formulations; a 750 mg strength is not standard or widely recognized.
Patient Guidelines
- Take the medicine regularly as prescribed.
- Understand that symptomatic relief is slow and may take several weeks.
- Report persistent diarrhea or signs of liver problems (e.g., dark urine, yellow skin/eyes) to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Diacerein is not known to impair the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a healthy weight to reduce stress on joints.
- Engage in regular, low-impact exercise suitable for osteoarthritis (e.g., swimming, walking).
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.