Orgabion
Generic Name
Thiamine Hydrochloride (Vitamin B1), Pyridoxine Hydrochloride (Vitamin B6), Cyanocobalamin (Vitamin B12)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| orgabion 100 mg tablet | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Orgabion-100 mg tablet is a B-complex vitamin supplement containing high doses of Thiamine (B1), Pyridoxine (B6), and Cyanocobalamin (B12). It is primarily used to prevent and treat deficiencies of these vitamins, especially in conditions affecting the nervous system.
Uses & Indications
Dosage
Adults
Usually 1 tablet 1-3 times daily, or as directed by physician.
Elderly
No specific dose adjustment required, follow adult dosage.
Renal_impairment
No specific dose adjustment required for mild to moderate impairment. Consult physician for severe renal impairment.
How to Take
Orally, with or without food.
Mechanism of Action
B vitamins act as coenzymes in various metabolic processes essential for carbohydrate, protein, and fat metabolism, nerve function, and red blood cell formation. Thiamine is crucial for nerve impulse transmission, Pyridoxine for amino acid metabolism and neurotransmitter synthesis, and Cyanocobalamin for DNA synthesis and nerve myelin sheath formation.
Pharmacokinetics
Onset
Effects observed gradually with regular use.
Excretion
Excreted primarily via the kidneys in urine.
Half life
Variable depending on the specific vitamin; water-soluble vitamins are generally not stored in large amounts and are rapidly excreted.
Absorption
Well absorbed from the gastrointestinal tract.
Metabolism
Metabolized in the liver to active coenzyme forms.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation
Drug Interactions
Levodopa
Pyridoxine may reduce the effect of Levodopa unless a decarboxylase inhibitor is also given.
Isoniazid, Penicillamine
Can interfere with Pyridoxine metabolism.
Phenobarbital, Phenytoin
High doses of Pyridoxine may reduce their plasma concentrations.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
High doses are generally well-tolerated as B vitamins are water-soluble. However, extremely high doses of Pyridoxine may lead to sensory neuropathy. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Generally considered safe in recommended doses. Consult a doctor for use during pregnancy and lactation, especially for high doses.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic
Clinical Trials
Extensive clinical data available for individual B vitamins regarding their efficacy in deficiency states and neuropathy management. Combination products build upon the established roles of each vitamin.
Lab Monitoring
- No routine lab monitoring typically required for supplementation. For specific deficiency diagnoses, blood levels of individual B vitamins may be monitored.
Doctor Notes
- This B-complex formulation is particularly important for patients with conditions like diabetes, chronic alcohol abuse, or malabsorption syndromes who are at higher risk of B vitamin deficiencies.
- Emphasize the importance of patient adherence to the prescribed dosage and duration for optimal therapeutic outcomes.
Patient Guidelines
- Take as directed by your doctor or pharmacist.
- Do not exceed the recommended dose.
- Store properly as instructed.
- Consult your doctor if symptoms persist or worsen.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double dose.
Driving Precautions
Generally, Orgabion-100 mg tablet has no known adverse effects on the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in essential nutrients.
- Avoid excessive alcohol consumption.
- Regular exercise can support overall health and nerve function.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.