Orgacef
Generic Name
Cefixime
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| orgacef 250 mg capsule | ৳ 6.52 | ৳ 26.08 |
Description
Overview of the medicine
Cefixime is an oral third-generation cephalosporin antibiotic used to treat various bacterial infections including those of the urinary tract, respiratory tract, otitis media, and gonorrhoea.
Uses & Indications
Dosage
Adults
The usual adult dose is 400 mg once daily or 200 mg every 12 hours. For uncomplicated gonorrhea, a single dose of 400 mg.
Elderly
No dosage adjustment usually required unless severe renal impairment (creatinine clearance < 60 mL/min).
Renal_impairment
For creatinine clearance 21-60 mL/min, the dose should be reduced to 75% of the standard dose. For creatinine clearance < 20 mL/min, the dose should be reduced to 50% of the standard dose.
How to Take
Orgacef 250 mg capsule can be taken with or without food. It should be swallowed whole with water.
Mechanism of Action
Cefixime inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death. It is bactericidal.
Pharmacokinetics
Onset
1-2 hours (peak plasma concentration)
Excretion
Primarily excreted unchanged in urine (about 50%) and bile (about 10%).
Half life
Average 3-4 hours (ranging from 2-6 hours)
Absorption
Approximately 40-50% absorbed orally. Food may delay absorption but does not significantly affect the extent of absorption.
Metabolism
Limited hepatic metabolism; primarily excreted as unchanged drug.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of serious hypersensitivity reactions (e.g., anaphylaxis) to penicillin or other beta-lactam antibiotics.
Drug Interactions
Nifedipine
May increase Cefixime absorption.
Carbamazepine
Concomitant use with cefixime has been shown to increase carbamazepine levels.
Anticoagulants (e.g., Warfarin)
May increase prothrombin time (INR); careful monitoring and dosage adjustment of anticoagulants may be necessary.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Hemodialysis and peritoneal dialysis are generally not effective in removing cefixime. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
- History of serious hypersensitivity reactions (e.g., anaphylaxis) to penicillin or other beta-lactam antibiotics.
Drug Interactions
Nifedipine
May increase Cefixime absorption.
Carbamazepine
Concomitant use with cefixime has been shown to increase carbamazepine levels.
Anticoagulants (e.g., Warfarin)
May increase prothrombin time (INR); careful monitoring and dosage adjustment of anticoagulants may be necessary.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. Hemodialysis and peritoneal dialysis are generally not effective in removing cefixime. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Cefixime is excreted in small amounts in breast milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from the date of manufacture, depending on the specific product and manufacturer guidelines.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in treating a broad spectrum of bacterial infections. Ongoing post-marketing surveillance continues to monitor its long-term effects and safety profile.
Lab Monitoring
- Renal function tests (especially in patients with pre-existing renal impairment or during prolonged therapy)
- Complete blood count (in patients on prolonged therapy)
Doctor Notes
- Prescribe cefixime judiciously, adhering to guidelines for appropriate antibiotic use to mitigate resistance.
- Always consider renal function when dosing, especially in elderly or renally impaired patients, and adjust as necessary.
- Emphasize to patients the importance of completing the entire prescribed course of therapy, even if symptoms improve, to ensure eradication of infection.
Patient Guidelines
- Complete the full course of treatment even if symptoms improve to prevent antibiotic resistance.
- Do not skip doses or stop taking the medication early.
- Inform your doctor immediately if you experience severe diarrhea or allergic reactions.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Cefixime may cause dizziness in some patients. Patients should be advised to be cautious when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain good personal hygiene to prevent reinfection.
- Drink plenty of fluids to stay hydrated, especially if experiencing diarrhea.
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Global Brand Names
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