Orifen
Generic Name
Flurbiprofen 100 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| orifen 100 mg tablet | ৳ 2.51 | ৳ 25.10 |
Description
Overview of the medicine
Orifen 100 mg Tablet contains Flurbiprofen, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and fever.
Uses & Indications
Dosage
Adults
50-100 mg, 2-3 times daily, maximum 300 mg/day. Take with food or milk.
Elderly
Lower doses initially, with careful monitoring due to increased risk of adverse effects.
Renal_impairment
Dose reduction may be necessary; avoid in severe renal impairment.
How to Take
Take orally, preferably with food or milk to minimize gastrointestinal discomfort.
Mechanism of Action
Flurbiprofen inhibits prostaglandin synthesis by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing pain and inflammation.
Pharmacokinetics
Onset
Analgesic effect within 30-60 minutes.
Excretion
Primarily excreted in urine as metabolites and unconjugated drug.
Half life
Approximately 3-6 hours.
Absorption
Rapid and complete absorption after oral administration. Peak plasma concentrations reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver via CYP2C9, primarily to 4'-hydroxyflurbiprofen.
Side Effects
Contraindications
- Hypersensitivity to flurbiprofen or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium and Methotrexate
Increased plasma levels of lithium and methotrexate, leading to toxicity.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Other NSAIDs and Corticosteroids
Increased risk of gastrointestinal adverse effects.
Diuretics and ACE inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Antiplatelet agents (e.g., Aspirin, Clopidogrel)
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, epigastric pain, gastrointestinal bleeding, drowsiness, dizziness, tinnitus, and acute renal failure. Management is supportive and symptomatic; gastric lavage or activated charcoal may be considered if ingestion was recent.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of the ductus arteriosus. Use with caution in the first and second trimesters only if the potential benefit outweighs the potential risk. Avoid during lactation.
Side Effects
Contraindications
- Hypersensitivity to flurbiprofen or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe heart failure
- Severe renal or hepatic impairment
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium and Methotrexate
Increased plasma levels of lithium and methotrexate, leading to toxicity.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Other NSAIDs and Corticosteroids
Increased risk of gastrointestinal adverse effects.
Diuretics and ACE inhibitors/ARBs
Reduced antihypertensive effect and increased risk of renal impairment.
Antiplatelet agents (e.g., Aspirin, Clopidogrel)
Increased risk of gastrointestinal bleeding.
Storage
Store below 30°C, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, epigastric pain, gastrointestinal bleeding, drowsiness, dizziness, tinnitus, and acute renal failure. Management is supportive and symptomatic; gastric lavage or activated charcoal may be considered if ingestion was recent.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to risk of premature closure of the ductus arteriosus. Use with caution in the first and second trimesters only if the potential benefit outweighs the potential risk. Avoid during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
DGDA Approved
Patent Status
Off-patent
Clinical Trials
Numerous clinical trials have established the efficacy and safety of flurbiprofen in various pain and inflammatory conditions.
Lab Monitoring
- Renal function tests (serum creatinine, BUN)
- Liver function tests (ALT, AST)
- Complete blood count (CBC) for long-term therapy
Doctor Notes
- Prescribe the lowest effective dose for the shortest possible duration consistent with treatment goals.
- Monitor renal and hepatic function, and blood pressure regularly in patients on long-term therapy.
- Educate patients about potential gastrointestinal and cardiovascular risks.
Patient Guidelines
- Take with food or milk to minimize stomach upset.
- Do not exceed the recommended dose.
- Report any signs of gastrointestinal bleeding (e.g., black, tarry stools) or allergic reactions.
- Avoid concomitant use with other NSAIDs.
Missed Dose Advice
If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances. Patients should be cautious when driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption while taking this medication to reduce the risk of stomach bleeding.
- Maintain a healthy diet and lifestyle as advised by your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.