Oriham
Generic Name
Omeprazole
Manufacturer
Opsonin Pharma Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| oriham 10 mg capsule | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Oriham 10 mg Capsule contains Omeprazole, a proton pump inhibitor used to reduce stomach acid production. It is prescribed for conditions like gastroesophageal reflux disease (GERD), ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
Mild GERD/Dyspepsia: 10-20 mg once daily. For other conditions, dosage varies from 20-60 mg daily.
Elderly
No specific dose adjustment is required in elderly patients, but caution is advised in patients with severe hepatic impairment.
Renal_impairment
No dose adjustment needed for renal impairment.
How to Take
Take orally, usually once daily, before a meal (preferably in the morning). Swallow the capsule whole with water; do not chew or crush.
Mechanism of Action
Omeprazole is a proton pump inhibitor that irreversibly blocks the H+/K+-ATPase enzyme system, the 'proton pump', in the gastric parietal cells. This reduces gastric acid secretion.
Pharmacokinetics
Onset
1-2 hours
Excretion
Mainly excreted in urine (approximately 80%) and feces (approximately 20%) as metabolites.
Half life
0.5-1 hour (plasma half-life), but the duration of action is much longer due to irreversible binding to the proton pump.
Absorption
Rapidly absorbed from the gastrointestinal tract, bioavailability is about 30-40% due to first-pass metabolism.
Metabolism
Extensively metabolized in the liver via CYP2C19 and CYP3A4 enzymes.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or any components of the formulation
- Concomitant use with nelfinavir
Drug Interactions
Warfarin
Increased INR and bleeding risk
Nelfinavir
Decreased nelfinavir levels
Clopidogrel
May reduce the antiplatelet effect of clopidogrel
Methotrexate
Increased methotrexate levels
Diazepam, Phenytoin, Citalopram
Increased plasma levels of these drugs
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. No specific antidote; treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy category C. Use during pregnancy only if clearly needed. Excreted in breast milk, use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or any components of the formulation
- Concomitant use with nelfinavir
Drug Interactions
Warfarin
Increased INR and bleeding risk
Nelfinavir
Decreased nelfinavir levels
Clopidogrel
May reduce the antiplatelet effect of clopidogrel
Methotrexate
Increased methotrexate levels
Diazepam, Phenytoin, Citalopram
Increased plasma levels of these drugs
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. No specific antidote; treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy category C. Use during pregnancy only if clearly needed. Excreted in breast milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Omeprazole for acid-related disorders across various patient populations.
Lab Monitoring
- No routine lab monitoring required for short-term use. Long-term use may require monitoring for Vitamin B12 deficiency, magnesium levels, and bone mineral density.
Doctor Notes
- Assess patient for H. pylori infection where appropriate.
- Educate patients on potential long-term risks, especially for those on prolonged therapy.
- Consider drug interactions, particularly with clopidogrel and nelfinavir.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking this medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
- Report any severe or persistent side effects.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once.
Driving Precautions
Omeprazole usually does not affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid driving.
Lifestyle Advice
- Avoid large meals, especially close to bedtime.
- Avoid trigger foods like fatty, spicy, acidic foods, caffeine, and alcohol.
- Elevate the head of your bed if you have GERD.
- Maintain a healthy weight.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.