Orioplex
Generic Name
Orioplex-5-mg-tablet
Manufacturer
PharmaGlobal Inc.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| orioplex 5 mg tablet | ৳ 0.51 | ৳ 22.95 |
Description
Overview of the medicine
Orioplex 5 mg tablet is an antidepressant medication used to treat major depressive disorder, generalized anxiety disorder, and panic disorder. It helps restore the balance of a certain natural substance (serotonin) in the brain.
Uses & Indications
Dosage
Adults
Initial dose 5 mg once daily, preferably in the morning. May be increased to 10-20 mg daily after several weeks based on response.
Elderly
Initial dose 5 mg once daily. Max recommended dose is 10 mg daily due to reduced metabolic clearance.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. Use with caution in severe impairment.
How to Take
Take Orioplex 5 mg tablet orally, with or without food. It can be taken at any time of day, but consistency (e.g., always in the morning) is recommended.
Mechanism of Action
Orioplex selectively inhibits the reuptake of serotonin (5-HT) by neurons in the central nervous system, thereby increasing the concentration of 5-HT in the synaptic cleft and enhancing serotonergic neurotransmission.
Pharmacokinetics
Onset
Initial therapeutic effects may be observed within 1-2 weeks, with full antidepressant effects usually seen after 4-6 weeks of consistent treatment.
Excretion
Mainly excreted in the urine (approximately 60%) and feces (approximately 40%) as metabolites.
Half life
Approximately 24-36 hours, allowing for once-daily dosing.
Absorption
Well absorbed orally, with peak plasma concentrations achieved within 4-6 hours.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 enzymes (CYP2C19, CYP3A4, and CYP2D6).
Side Effects
Contraindications
- Hypersensitivity to Orioplex or any component of the tablet.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy.
Drug Interactions
MAOIs
Concurrent use can lead to serious, sometimes fatal, reactions including Serotonin Syndrome.
NSAIDs
Increased risk of gastrointestinal bleeding.
Warfarin
May increase anticoagulant effect, requiring close INR monitoring.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, dizziness, tachycardia, tremor, and rarely, seizures. Treatment is symptomatic and supportive. Maintain an open airway, monitor cardiac and vital signs. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to Orioplex or any component of the tablet.
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy.
Drug Interactions
MAOIs
Concurrent use can lead to serious, sometimes fatal, reactions including Serotonin Syndrome.
NSAIDs
Increased risk of gastrointestinal bleeding.
Warfarin
May increase anticoagulant effect, requiring close INR monitoring.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, nausea, vomiting, dizziness, tachycardia, tremor, and rarely, seizures. Treatment is symptomatic and supportive. Maintain an open airway, monitor cardiac and vital signs. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patent pending
Clinical Trials
Extensive Phase III clinical trials demonstrated efficacy and safety in patients with major depressive disorder and anxiety disorders, involving over 2000 patients globally.
Lab Monitoring
- Baseline and periodic liver function tests (LFTs) in patients with hepatic impairment.
- Baseline and periodic renal function tests in patients with severe renal impairment.
- Electrolyte levels, especially sodium, if hyponatremia is suspected.
Doctor Notes
- Always initiate with the lowest effective dose and titrate slowly.
- Educate patients about the delayed onset of action and the importance of adherence.
- Monitor for signs of worsening depression, suicidality, and emergence of adverse events, particularly during initial therapy and dose changes.
Patient Guidelines
- Do not stop taking Orioplex suddenly without consulting your doctor, as this can lead to withdrawal symptoms.
- It may take several weeks to feel the full benefits of this medicine.
- Report any worsening depression or suicidal thoughts to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Orioplex may cause drowsiness, dizziness, or blurred vision. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Avoid alcohol consumption while taking Orioplex as it may increase side effects like drowsiness and dizziness.
- Regular exercise and a balanced diet can complement the treatment.
- Practice stress-reduction techniques like meditation or yoga.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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