Orocur
Generic Name
orocure-67-mg-pediatric-drop
Manufacturer
Local Pharma Co. Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| orocure 67 mg pediatric drop | ৳ 30.00 | N/A |
Description
Overview of the medicine
Orocur 67 mg Pediatric Drop is a medication containing Paracetamol (Acetaminophen), primarily used for fever reduction and pain relief in infants and children. It is formulated as an oral drop for easy administration.
Uses & Indications
Dosage
Adults
Not typically recommended for adults in this specific pediatric formulation. Adult dosages of Paracetamol vary, consult product specific to adults.
Elderly
Not typically recommended for elderly in this specific pediatric formulation.
Renal_impairment
Dosage adjustment may be necessary in severe renal impairment. Consult physician.
How to Take
Administer orally using the provided dropper. Ensure the correct dose is measured. Can be given with or without food. Shake the bottle well before use.
Mechanism of Action
Paracetamol is thought to act primarily in the central nervous system, increasing the pain threshold by inhibiting cyclooxygenase (COX) enzymes, particularly COX-2, which are involved in prostaglandin synthesis. It also has antipyretic effects by acting on the hypothalamic heat-regulating center, leading to peripheral vasodilation and sweating.
Pharmacokinetics
Onset
Within 30-60 minutes for analgesia and antipyresis.
Excretion
Mainly excreted in the urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
Approximately 1.5 to 3 hours in adults; slightly longer in neonates and shorter in young children.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 30 to 60 minutes after oral administration.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation pathways. A small amount is metabolized by cytochrome P450 enzymes to a toxic intermediate, N-acetyl-p-benzoquinone imine (NAPQI), which is rapidly detoxified by glutathione.
Side Effects
Contraindications
- Hypersensitivity to Paracetamol or any component of the formulation
- Severe hepatic impairment
Drug Interactions
Alcohol
Increases the risk of hepatotoxicity with chronic alcohol consumption.
Warfarin
May increase the anticoagulant effect of warfarin, leading to an increased risk of bleeding, especially with prolonged use of high doses.
Other Paracetamol-containing products
Increased risk of overdose and hepatotoxicity.
Phenobarbital, Phenytoin, Carbamazepine
May increase the risk of hepatotoxicity due to increased metabolism of paracetamol.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Do not freeze.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, and liver damage (jaundice). Severe overdose can lead to hepatic necrosis, renal tubular necrosis, and death. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at recommended doses, but consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to Paracetamol or any component of the formulation
- Severe hepatic impairment
Drug Interactions
Alcohol
Increases the risk of hepatotoxicity with chronic alcohol consumption.
Warfarin
May increase the anticoagulant effect of warfarin, leading to an increased risk of bleeding, especially with prolonged use of high doses.
Other Paracetamol-containing products
Increased risk of overdose and hepatotoxicity.
Phenobarbital, Phenytoin, Carbamazepine
May increase the risk of hepatotoxicity due to increased metabolism of paracetamol.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Do not freeze.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, and liver damage (jaundice). Severe overdose can lead to hepatic necrosis, renal tubular necrosis, and death. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at recommended doses, but consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date, refer to product label.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
As Paracetamol is a well-established medicine, extensive clinical trials have been conducted over decades, demonstrating its efficacy and safety for fever and pain management. New formulations may undergo bioequivalence studies.
Lab Monitoring
- Liver function tests (ALT, AST) if used long-term or in cases of suspected overdose.
- Renal function tests if renal impairment is present.
Doctor Notes
- Advise parents on proper dosing based on child's weight/age.
- Caution against concomitant use of other Paracetamol-containing products.
- Monitor for signs of allergic reactions or liver dysfunction.
Patient Guidelines
- Do not exceed the recommended dose.
- Consult a doctor if fever persists for more than 3 days or pain for more than 5 days.
- Keep out of reach of children.
- Read the label carefully before use.
Missed Dose Advice
If a dose is missed, administer it as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Orocur 67 mg Pediatric Drop is not expected to affect the ability to drive or operate machinery, as it is primarily for pediatric use and does not cause drowsiness in therapeutic doses.
Lifestyle Advice
- Ensure adequate fluid intake, especially during fever.
- Rest is important for recovery from illness.
- Follow a balanced diet.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.