Orpa-Plus
Generic Name
Omeprazole + Metronidazole
Manufacturer
Hypothetical Pharma Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| orpa plus 500 mg tablet | ৳ 1.90 | ৳ 19.00 |
Description
Overview of the medicine
Orpa-Plus 500 mg Tablet is a combination medicine containing Omeprazole and Metronidazole, primarily used for the treatment of Helicobacter pylori infection and related gastrointestinal disorders, such as peptic ulcers.
Uses & Indications
Dosage
Adults
For H. pylori eradication, typically Omeprazole 20 mg twice daily + Metronidazole 500 mg twice daily (often with a third antibiotic like Amoxicillin or Clarithromycin) for 7-14 days, as directed by physician.
Elderly
No specific dose adjustment typically required, but monitor for side effects due to potential altered pharmacokinetics.
Renal_impairment
Metronidazole dose reduction may be necessary in severe renal impairment (CrCl <10 mL/min). No omeprazole adjustment for mild to moderate.
How to Take
Take the tablet whole with water, preferably before meals. Do not chew or crush.
Mechanism of Action
Omeprazole, a Proton Pump Inhibitor, reduces stomach acid production by irreversibly blocking the H+/K+-ATPase pump in gastric parietal cells. Metronidazole, a nitroimidazole antibiotic, exerts its bactericidal effect by damaging microbial DNA, particularly against anaerobic bacteria and certain protozoa.
Pharmacokinetics
Onset
Omeprazole: Acid secretion inhibition within 1 hour. Metronidazole: Rapid.
Excretion
Omeprazole: Primarily renal (70-80%). Metronidazole: Primarily renal (60-80%), some fecal.
Half life
Omeprazole: 0.5-1 hour (plasma), longer duration of action due to irreversible pump inhibition. Metronidazole: 6-11 hours.
Absorption
Omeprazole is rapidly absorbed, bioavailability ~30-40%. Metronidazole is rapidly and completely absorbed, bioavailability >90%.
Metabolism
Omeprazole: Extensively metabolized by CYP2C19 and CYP3A4 in the liver. Metronidazole: Hepatic metabolism via oxidation.
Side Effects
Contraindications
- •Hypersensitivity to Omeprazole, Metronidazole, or any component
- •Known neurological disorders (for Metronidazole)
- •First trimester of pregnancy (Metronidazole)
Drug Interactions
Alcohol
Disulfiram-like reaction (Metronidazole)
Warfarin
Increased anticoagulant effect (Metronidazole)
Clopidogrel
Reduced antiplatelet effect (Omeprazole)
Phenytoin/Phenobarbital
Altered metabolism, increased levels of phenytoin (Metronidazole), decreased omeprazole levels (Phenobarbital)
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture.
Overdose
Symptoms of overdose may include nausea, vomiting, ataxia, disorientation, and seizures. Treatment is symptomatic and supportive; no specific antidote.
Pregnancy & Lactation
Use with caution. Metronidazole is generally avoided in the first trimester of pregnancy. Consult a doctor. Both components pass into breast milk; consider alternatives or temporary discontinuation of breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved in various countries for H. pylori eradication
Patent Status
Generically available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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