Orpra
Generic Name
Omeprazole 20 mg
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| orpra 20 mg capsule | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Orpra 20 mg Capsule contains Omeprazole, a proton pump inhibitor, used to reduce the amount of acid produced in the stomach. It treats conditions like heartburn, acid reflux, and peptic ulcers.
Uses & Indications
Dosage
Adults
Typically 20-40 mg once daily, depending on the condition. For GERD, 20 mg once daily for 4-8 weeks. For duodenal ulcer, 20 mg once daily for 2-4 weeks. For gastric ulcer, 20 mg once daily for 4-8 weeks.
Elderly
No dosage adjustment is generally required, but caution is advised in patients with severe hepatic impairment.
Renal_impairment
No dosage adjustment is generally required for patients with impaired renal function.
How to Take
Orally, preferably in the morning before a meal. Swallow the capsule whole with water. Do not chew or crush.
Mechanism of Action
Omeprazole works by irreversibly binding to and inhibiting the H+/K+-ATPase (proton pump) in the parietal cells of the stomach, thereby blocking the final step in gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour; maximal acid suppression in 2 hours.
Excretion
Mainly excreted in urine (approximately 80%) and feces (approximately 20%) as metabolites.
Half life
0.5-1 hour (terminal half-life), but the duration of acid suppression is much longer (up to 72 hours) due to irreversible binding.
Absorption
Rapidly absorbed from the gastrointestinal tract, though absorption is variable. Bioavailability is approximately 30-40% after a single dose.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 system, particularly by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or any component of the formulation
- Concomitant use with nelfinavir
Drug Interactions
Digoxin
Increased digoxin absorption and levels; monitor.
Warfarin
Increased INR/prothrombin time; monitor closely.
Tacrolimus
Increased tacrolimus levels; monitor.
Clopidogrel
Omeprazole can reduce the antiplatelet effect of clopidogrel. Avoid concomitant use or consider alternative antiplatelet therapy.
Methotrexate
Increased methotrexate levels; adjust dose or monitor.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive. Omeprazole is not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Excreted in breast milk; caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or any component of the formulation
- Concomitant use with nelfinavir
Drug Interactions
Digoxin
Increased digoxin absorption and levels; monitor.
Warfarin
Increased INR/prothrombin time; monitor closely.
Tacrolimus
Increased tacrolimus levels; monitor.
Clopidogrel
Omeprazole can reduce the antiplatelet effect of clopidogrel. Avoid concomitant use or consider alternative antiplatelet therapy.
Methotrexate
Increased methotrexate levels; adjust dose or monitor.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive. Omeprazole is not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Excreted in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Available in pharmacies worldwide
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established omeprazole's efficacy and safety for acid-related disorders. Ongoing studies explore long-term safety and new applications.
Lab Monitoring
- Monitor liver function tests periodically in patients with severe hepatic impairment.
- Monitor magnesium levels in patients on prolonged therapy (three months or more).
Doctor Notes
- Advise patients about potential long-term risks with PPIs.
- Consider lowest effective dose for shortest duration.
- Check for drug interactions, especially with clopidogrel and methotrexate.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Do not stop taking it suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances. If affected, do not drive or operate machinery.
Lifestyle Advice
- Avoid trigger foods and beverages (e.g., spicy food, caffeine, alcohol).
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.