Osecton
Generic Name
Omeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| osecton 20 mg capsule | ৳ 3.50 | N/A |
Description
Overview of the medicine
Omeprazole is a proton pump inhibitor used to treat conditions caused by excess stomach acid, such as ulcers, GERD, and erosive esophagitis.
Uses & Indications
Dosage
Adults
Typically 20 mg once daily for 4-8 weeks for GERD and ulcers. Higher doses may be used for severe conditions like Zollinger-Ellison syndrome.
Elderly
No specific dose adjustment is generally required, but use with caution due to potential decreased liver function.
Renal_impairment
No dose adjustment is needed for patients with impaired renal function.
How to Take
Take orally, preferably in the morning, at least 30 minutes before a meal. Swallow the capsule whole with water; do not chew or crush it.
Mechanism of Action
Omeprazole works by irreversibly blocking the H+/K+-ATPase enzyme system (proton pump) in the gastric parietal cells, thereby reducing gastric acid secretion.
Pharmacokinetics
Onset
1-2 hours
Excretion
Mainly via urine (approximately 77%) and feces (approximately 18%).
Half life
0.5-1 hour (terminal elimination half-life is longer due to irreversible binding to the proton pump)
Absorption
Rapidly absorbed from the gastrointestinal tract after oral administration. Bioavailability is approximately 30-40%, increasing with repeated dosing.
Metabolism
Extensively metabolized in the liver via cytochrome P450 enzymes (primarily CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to omeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Warfarin
Increased INR and bleeding risk.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel (clinical significance debated, often avoided).
Methotrexate
Increased methotrexate levels, particularly with high-dose therapy.
Diazepam, Phenytoin
Increased plasma levels of these drugs.
Nelfinavir, Atazanavir
Reduced plasma concentrations and efficacy of antivirals.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include confusion, drowsiness, blurred vision, tachycardia, nausea, vomiting, sweating, and headache. Management is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed and potential benefits outweigh risks. Omeprazole is excreted in breast milk; use with caution in lactating women.
Side Effects
Contraindications
- Hypersensitivity to omeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Warfarin
Increased INR and bleeding risk.
Clopidogrel
May reduce the antiplatelet effect of clopidogrel (clinical significance debated, often avoided).
Methotrexate
Increased methotrexate levels, particularly with high-dose therapy.
Diazepam, Phenytoin
Increased plasma levels of these drugs.
Nelfinavir, Atazanavir
Reduced plasma concentrations and efficacy of antivirals.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include confusion, drowsiness, blurred vision, tachycardia, nausea, vomiting, sweating, and headache. Management is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed and potential benefits outweigh risks. Omeprazole is excreted in breast milk; use with caution in lactating women.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date. Refer to the specific packaging for exact expiry.
Availability
Pharmacies, hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of omeprazole for various acid-related disorders, confirming its role as a cornerstone therapy in GI management.
Lab Monitoring
- Not routinely required.
- Consider monitoring magnesium levels with long-term use (typically >3 months) due to risk of hypomagnesemia.
- Monitor for signs of Vitamin B12 deficiency with prolonged use (>3 years).
Doctor Notes
- Advise patients about potential long-term risks of PPIs, especially with prolonged use.
- Consider using the lowest effective dose for the shortest possible duration to manage symptoms.
- Evaluate symptoms suggestive of underlying serious conditions (e.g., malignancy) before initiating PPI therapy.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor and complete the full course of treatment.
- Do not chew, crush, or open the capsule; swallow it whole.
- Inform your doctor if symptoms do not improve or worsen.
- Report any severe abdominal pain, black or tarry stools, or persistent vomiting.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double dose.
Driving Precautions
Omeprazole may cause dizziness or visual disturbances in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a healthy diet, avoiding spicy, fatty, or acidic foods that can trigger symptoms.
- Elevate the head of your bed for GERD symptoms.
- Manage stress, as it can worsen digestive issues.
- Avoid smoking and excessive alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.