Osmofundin
Generic Name
Mannitol
Manufacturer
The Acme Laboratories Ltd.
Country
Bangladesh
Loading images...
Description
Overview of the medicine
Mannitol is an osmotic diuretic used to promote diuresis and reduce intracranial pressure.
Uses & Indications
Dosage
Adults
0.25-2 g/kg body weight intravenously over 30-60 minutes.
Elderly
Lower end of the adult dosage range, adjusted for renal function.
Renal_impairment
Dosage adjustment necessary based on creatinine clearance.
How to Take
Administered intravenously by a healthcare professional.
Mechanism of Action
Mannitol increases the osmolarity of the glomerular filtrate, inhibiting tubular reabsorption of water and electrolytes, thus promoting diuresis.
Pharmacokinetics
Onset
Diuresis occurs within 1-3 hours.
Excretion
Primarily excreted unchanged in the urine.
Half life
Approximately 1.5 hours.
Absorption
Poorly absorbed orally; administered intravenously.
Metabolism
Minimal metabolism.
Side Effects
Contraindications
- Severe dehydration
- Active intracranial bleeding
Drug Interactions
Digoxin
Mannitol can decrease digoxin levels.
Lithium
Mannitol can increase lithium excretion.
Storage
Store at room temperature, away from light and moisture.
Overdose
Monitor fluid and electrolyte balance. Supportive treatment.
Pregnancy & Lactation
Use with caution during pregnancy; consult a doctor. Caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Hospitals, Pharmacies
Approval Status
DGDA Approved
Patent Status
Off Patent
Clinical Trials
Ongoing clinical trials investigating the use of Mannitol in traumatic brain injury.
Lab Monitoring
- Serum electrolytes
- Renal function tests
Doctor Notes
- Monitor renal function closely during therapy.
- Use with caution in patients with heart failure.
Patient Guidelines
- Report any signs of dehydration.
- Follow doctor's instructions carefully.
- Monitor urine output.
Missed Dose Advice
Not applicable, as administered in a clinical setting.
Driving Precautions
Not applicable.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid excessive salt intake.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.