Ossi-D
Generic Name
Calcium Carbonate + Vitamin D3
Manufacturer
Aura Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ossi d 500 mg tablet | ৳ 6.00 | N/A |
Description
Overview of the medicine
Ossi-D 500 mg Tablet is a combination medicine containing Calcium Carbonate and Vitamin D3 (Cholecalciferol), primarily used to prevent and treat calcium and vitamin D deficiencies. It is vital for maintaining strong bones and teeth, supporting muscle function, and preventing conditions like osteoporosis, osteomalacia, and rickets.
Uses & Indications
Dosage
Adults
Usually 1-2 tablets daily, or as directed by a physician. Best taken with food.
Elderly
Similar to adults, but renal function should be monitored due to increased risk of hypercalcemia in individuals with impaired renal function.
Renal_impairment
Use with caution. Dose adjustment may be required. Contraindicated in severe renal impairment and hypercalcaemia. Consult a doctor.
How to Take
Take the tablet whole with a glass of water. It is recommended to take it with a meal to enhance absorption and reduce gastric upset. Do not chew or crush the tablet.
Mechanism of Action
Calcium is an essential mineral required for bone formation, maintenance, and various physiological functions including nerve transmission and muscle contraction. Vitamin D3 facilitates the absorption of calcium from the gut, regulates calcium and phosphate levels in the blood, and promotes bone mineralization and remodeling.
Pharmacokinetics
Onset
Therapeutic effects on bone density and calcium levels are gradual, taking weeks to months for noticeable clinical improvement.
Excretion
Calcium: Unabsorbed calcium and excess absorbed calcium are excreted via kidneys (urine) and feces. Vitamin D3: Metabolites are primarily excreted in bile and feces, with smaller amounts excreted renally.
Half life
Calcium: Complex pharmacokinetics, not easily described by a single half-life. Vitamin D3 (Cholecalciferol): Half-life is about 15-20 days. Its active metabolite, calcitriol, has a much shorter half-life of hours.
Absorption
Calcium: Absorbed primarily in the small intestine via active transport (Vitamin D dependent) and passive diffusion. Vitamin D3: Absorbed from the small intestine, primarily in the jejunum, requiring bile salts for efficient absorption.
Metabolism
Calcium: Absorbed calcium is utilized or excreted. Vitamin D3: Hydroxylated in the liver to 25-hydroxyvitamin D (calcifediol), then further hydroxylated in the kidneys to 1,25-dihydroxyvitamin D (calcitriol), the active form.
Side Effects
Contraindications
- Hypercalcemia (high calcium levels in the blood)
- Hypercalciuria (high calcium levels in the urine)
- Hypervitaminosis D (excessive vitamin D levels)
- Nephrolithiasis (kidney stones) or a history of recurrent kidney stones
- Severe renal impairment
Drug Interactions
Levothyroxine
Calcium can interfere with levothyroxine absorption. Separate administration by at least 4 hours.
Bisphosphonates
Calcium can interfere with absorption. Administer calcium at least 30-60 minutes after bisphosphonates.
Corticosteroids
May reduce calcium absorption and increase calcium excretion, potentially necessitating higher calcium and Vitamin D doses.
Thiazide diuretics
May increase the risk of hypercalcemia by decreasing renal calcium excretion.
Tetracyclines & Quinolone antibiotics
Calcium can chelate these antibiotics, reducing their absorption. Administer calcium at least 2-3 hours before or 4-6 hours after these antibiotics.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose primarily relate to hypercalcemia, including nausea, vomiting, constipation, thirst, polyuria (frequent urination), weakness, and fatigue. Severe overdose can lead to renal impairment, cardiac arrhythmias, and coma. Management involves immediate discontinuation of the drug, hydration, and potentially loop diuretics. Close monitoring of serum calcium levels is crucial.
Pregnancy & Lactation
Generally considered safe and often recommended during pregnancy and lactation to meet the increased demands for calcium and Vitamin D, essential for fetal/infant bone development and maternal health. However, use only under medical supervision to ensure appropriate dosing and avoid exceeding recommended daily allowances.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the manufacturing date, consult product packaging for exact date.
Availability
Pharmacies, drug stores
Approval Status
Generally approved as a supplement (e.g., by DGDA/FDA)
Patent Status
Generic
Clinical Trials
Extensive clinical trials and epidemiological studies have consistently demonstrated the efficacy of calcium and Vitamin D supplementation in improving bone mineral density, reducing fracture risk, and preventing deficiencies in various populations, especially post-menopausal women and the elderly.
Lab Monitoring
- Serum calcium levels (especially in long-term therapy, high doses, or in patients with renal impairment)
- Serum 25-hydroxyvitamin D levels (to assess Vitamin D status)
- Renal function (e.g., serum creatinine) in patients with kidney impairment or on long-term therapy
- Urinary calcium excretion (if hypercalciuria is suspected)
Doctor Notes
- Crucial for bone health, especially in post-menopausal women, elderly, and individuals with calcium/Vitamin D deficiency. Assess patient's dietary intake and sun exposure.
- Monitor serum calcium, 25-hydroxyvitamin D, and renal function (e.g., creatinine) in patients on long-term therapy or with risk factors for hypercalcemia/renal impairment.
- Advise patients on potential drug-food interactions and appropriate timing for co-administered medications (e.g., antibiotics, levothyroxine).
Patient Guidelines
- Take the tablet as directed by your doctor, preferably with a meal.
- Do not exceed the recommended dose without consulting your healthcare provider.
- Inform your doctor if you have any pre-existing medical conditions, especially kidney disease, a history of kidney stones, or malabsorption issues.
- Avoid taking other calcium-containing supplements or antacids without medical advice to prevent excessive calcium intake.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose to compensate for a missed one.
Driving Precautions
Ossi-D 500 mg Tablet is not known to affect the ability to drive or operate machinery. However, if you experience any side effects that impair your concentration or vision, avoid such activities.
Lifestyle Advice
- Maintain a balanced diet rich in calcium (e.g., dairy products, fortified foods, leafy green vegetables) and Vitamin D (e.g., fatty fish, fortified milk).
- Engage in regular weight-bearing exercises (e.g., walking, jogging) to promote bone strength.
- Ensure adequate, safe sun exposure for natural Vitamin D synthesis, while protecting skin from harmful UV rays.
- Avoid excessive alcohol intake and smoking, which can negatively impact bone health.
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