Ostim
Generic Name
Calcium Orotate 500 mg
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ostim 500 mg tablet | ৳ 2.52 | N/A |
Description
Overview of the medicine
Ostim 500 mg Tablet contains Calcium Orotate, a highly bioavailable form of calcium, used to prevent and treat calcium deficiencies and support bone health.
Uses & Indications
Dosage
Adults
Typically 500-1000 mg (1-2 tablets) orally daily, preferably with meals or as directed by a physician.
Elderly
Same as adult dosage, but caution should be exercised in individuals with impaired renal function. Consult a physician.
Renal_impairment
Use with caution and dose adjustment may be necessary. Regular monitoring of serum calcium levels is recommended. Contraindicated in severe renal impairment.
How to Take
Take the tablet orally with water, preferably with a meal to enhance absorption and reduce potential gastrointestinal upset. Do not crush or chew the tablet unless advised by a doctor.
Mechanism of Action
Calcium Orotate provides elemental calcium, an essential mineral required for bone formation, muscle contraction, nerve transmission, and various enzymatic reactions. Orotate acts as a carrier molecule, enhancing the cellular absorption and utilization of calcium, thereby potentially offering superior bioavailability compared to other calcium salts.
Pharmacokinetics
Onset
Therapeutic effects may be observed over days to weeks, depending on the severity of calcium deficiency.
Excretion
Calcium is primarily excreted via the kidneys and through feces. A small amount is lost through sweat.
Half life
The half-life of calcium in the body is complex and varies depending on its physiological role (e.g., bone vs. plasma). Orotate itself is metabolized.
Absorption
Calcium Orotate is known for its relatively higher bioavailability due to the orotate carrier, which facilitates efficient absorption into cells and tissues. Absorption primarily occurs in the small intestine.
Metabolism
Elemental calcium is not metabolized. The orotate component is metabolized by the liver.
Side Effects
Contraindications
- Hypersensitivity to Calcium Orotate or any component of the formulation
- Hypercalcemia (abnormally high levels of calcium in the blood)
- Hypercalciuria (abnormally high levels of calcium in the urine)
- Severe renal impairment
- Renal calculi (kidney stones)
Drug Interactions
Digoxin
High calcium levels can increase the risk of digoxin toxicity. Monitor serum calcium and digoxin levels.
Bisphosphonates
Calcium can interfere with the absorption of bisphosphonates. Administer calcium at least 30 minutes after taking bisphosphonates.
Corticosteroids
May decrease calcium absorption.
Thiazide Diuretics
May reduce calcium excretion, increasing the risk of hypercalcemia.
Thyroid hormones (e.g., Levothyroxine)
Calcium can decrease the absorption of thyroid hormones. Administer at least 4 hours apart.
Tetracycline and Fluoroquinolone Antibiotics
Calcium can reduce the absorption of these antibiotics. Administer at least 2-3 hours before or 4-6 hours after calcium.
Storage
Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose (hypercalcemia) may include nausea, vomiting, constipation, abdominal pain, muscle weakness, polyuria, polydipsia, and in severe cases, cardiac arrhythmias. Treatment involves discontinuing calcium supplementation, ensuring adequate hydration, and managing symptoms. Medical attention is required.
Pregnancy & Lactation
Calcium requirements increase during pregnancy and lactation. Calcium Orotate can generally be used during these periods under medical supervision. Consult your doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture. Check the expiry date on the packaging.
Availability
Pharmacies, online drugstores
Approval Status
Approved (as a supplement)
Patent Status
Off-patent
Clinical Trials
Clinical studies have investigated the bioavailability and efficacy of Calcium Orotate in calcium supplementation and bone health.
Lab Monitoring
- Serum calcium levels (especially in patients with renal impairment or those at risk of hypercalcemia)
- Urinary calcium excretion (if hypercalciuria is suspected)
- Renal function tests (e.g., creatinine, BUN) in patients with kidney issues
Doctor Notes
- Consider baseline and periodic monitoring of serum calcium, especially in patients with pre-existing conditions or on concomitant medications.
- Advise patients on proper administration to optimize absorption and minimize interactions (e.g., separate from certain antibiotics).
- Educate on signs of hypercalcemia and the importance of hydration.
Patient Guidelines
- Take exactly as prescribed or directed on the label.
- Do not exceed the recommended dose without consulting a healthcare professional.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Maintain adequate hydration by drinking plenty of fluids.
- Report any unusual or severe side effects to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Ostim 500 mg Tablet is generally not expected to affect the ability to drive or operate machinery. However, if you experience any side effects that impair your ability, avoid these activities.
Lifestyle Advice
- Regular weight-bearing exercise can help strengthen bones.
- Ensure a diet rich in calcium and Vitamin D, or consider additional Vitamin D supplementation.
- Avoid excessive alcohol consumption and smoking, as these can negatively impact bone health.
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Global Brand Names
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