Ostofid Plus
Generic Name
Glucosamine Sulfate & Chondroitin Sulfate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ostofid plus 250 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Ostofid Plus 250 mg Tablet is a combination supplement containing Glucosamine Sulfate and Chondroitin Sulfate, used to support joint health and manage symptoms of osteoarthritis.
Uses & Indications
Dosage
Adults
Typically, 1-2 tablets daily, or as directed by a physician. Higher doses (e.g., 500mg Glucosamine, 400mg Chondroitin, 3 times daily) are also common for different formulations.
Elderly
No specific dose adjustment needed, but caution in patients with comorbidities.
Renal_impairment
Use with caution in severe renal impairment. No specific guidelines, consult a physician.
How to Take
Oral. Can be taken with or without food. To minimize GI upset, take with food.
Mechanism of Action
Glucosamine is a natural amino sugar that plays a crucial role in building cartilage, while Chondroitin sulfate is a complex carbohydrate that helps cartilage retain water, improving elasticity and cushioning. Together, they help rebuild cartilage, reduce inflammation, and improve joint function.
Pharmacokinetics
Onset
Clinical effects are typically observed after 2-4 weeks of continuous use, with full benefits taking several months.
Excretion
Glucosamine is primarily excreted renally, with some fecal excretion. Chondroitin is primarily excreted renally.
Half life
Glucosamine has a plasma half-life of 15 hours. Chondroitin's half-life is around 3 hours.
Absorption
Glucosamine has an oral bioavailability of about 25-26%, while Chondroitin's bioavailability is around 10-20%.
Metabolism
Glucosamine is primarily metabolized in the liver. Chondroitin is partially metabolized via depolymerization and desulfation.
Side Effects
Contraindications
- Hypersensitivity to Glucosamine, Chondroitin, or any excipients
- Shellfish allergy (if Glucosamine derived from shellfish)
Drug Interactions
Warfarin
May enhance the anticoagulant effect, increasing risk of bleeding. Monitor INR closely.
Insulin/Antidiabetic agents
Glucosamine may affect glucose metabolism. Monitor blood glucose levels in diabetic patients.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Symptomatic and supportive treatment is recommended. High doses may cause gastrointestinal upset.
Pregnancy & Lactation
Insufficient data regarding safety in pregnancy and lactation. Avoid use or consult a physician.
Side Effects
Contraindications
- Hypersensitivity to Glucosamine, Chondroitin, or any excipients
- Shellfish allergy (if Glucosamine derived from shellfish)
Drug Interactions
Warfarin
May enhance the anticoagulant effect, increasing risk of bleeding. Monitor INR closely.
Insulin/Antidiabetic agents
Glucosamine may affect glucose metabolism. Monitor blood glucose levels in diabetic patients.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Symptomatic and supportive treatment is recommended. High doses may cause gastrointestinal upset.
Pregnancy & Lactation
Insufficient data regarding safety in pregnancy and lactation. Avoid use or consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months
Availability
Pharmacies, drugstores
Approval Status
Approved by local drug regulatory authorities
Patent Status
Off-patent
Clinical Trials
Numerous clinical trials support the efficacy of glucosamine and chondroitin in osteoarthritis symptoms, though results vary.
Lab Monitoring
- INR (for patients on warfarin)
- Blood glucose (for diabetic patients)
Doctor Notes
- Counsel patients on realistic expectations regarding onset of action.
- Advise on potential interaction with anticoagulants and blood glucose monitoring for diabetics.
Patient Guidelines
- Take as directed by your doctor or pharmacist.
- Consistency is key; long-term use is often required for benefits.
- Report any unusual side effects to your healthcare provider.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose and resume your regular schedule. Do not double the dose.
Driving Precautions
Generally considered safe. No known effects on driving ability.
Lifestyle Advice
- Maintain a healthy weight to reduce joint stress.
- Engage in regular, low-impact exercise.
- Follow a balanced diet rich in anti-inflammatory foods.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.