Ostogen-D Forte
Generic Name
Calcium Carbonate (equivalent to 600 mg elemental Calcium) + Vitamin D3 (400 IU)
Manufacturer
Leading Pharmaceutical Company
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ostogen d forte 600 mg tablet | ৳ 7.00 | N/A |
Description
Overview of the medicine
Ostogen-D Forte 600 mg Tablet is a combination supplement containing elemental calcium and Vitamin D3, primarily used to support bone health and prevent or treat deficiencies of these nutrients.
Uses & Indications
Dosage
Adults
Usually 1-2 tablets daily, preferably with meals, or as directed by the physician.
Elderly
No specific dosage adjustment is typically required; however, renal function should be monitored in elderly patients.
Renal_impairment
Use with caution. Dose adjustment may be necessary based on serum calcium and creatinine levels. Avoid in severe renal impairment.
How to Take
Oral, swallow whole with water. May be taken with or without food, but taking with food may improve absorption, especially for calcium carbonate.
Mechanism of Action
Calcium is an essential mineral required for bone formation and maintenance, muscle contraction, nerve function, and blood clotting. Vitamin D3 (cholecalciferol) facilitates the absorption of calcium from the gastrointestinal tract and helps regulate calcium and phosphate levels in the body, promoting proper bone mineralization.
Pharmacokinetics
Onset
Therapeutic effects on bone density are gradual, usually requiring several months of consistent supplementation.
Excretion
Unabsorbed calcium is excreted in feces. Absorbed calcium is primarily excreted by the kidneys. Vitamin D3 metabolites are primarily excreted via bile in feces, with a smaller amount via urine.
Half life
Elemental calcium has complex kinetics. Vitamin D3 has a half-life of about 24 hours, but its active metabolites have much longer half-lives (e.g., calcifediol 2-3 weeks, calcitriol 4-6 hours).
Absorption
Calcium carbonate requires stomach acid for absorption and is best absorbed with food. Vitamin D3 is fat-soluble and absorbed from the small intestine, primarily in the presence of bile salts.
Metabolism
Calcium is not metabolized. Vitamin D3 undergoes hydroxylation in the liver to calcifediol (25-hydroxyvitamin D3) and then in the kidneys to calcitriol (1,25-dihydroxyvitamin D3), the active form.
Side Effects
Contraindications
- Hypersensitivity to calcium carbonate, Vitamin D3, or any component of the formulation
- Hypercalcemia (abnormally high levels of calcium in the blood)
- Hypercalciuria (abnormally high levels of calcium in the urine)
- Severe renal impairment or kidney stones (nephrolithiasis)
- Vitamin D toxicity
Drug Interactions
Digoxin
High calcium levels can increase the risk of digoxin toxicity. Monitor carefully if co-administered.
Bisphosphonates
Calcium can interfere with the absorption of bisphosphonates. Administer calcium at least 30-60 minutes after bisphosphonates.
Thiazide diuretics
May increase the risk of hypercalcemia by reducing urinary calcium excretion.
Thyroid hormones (e.g., levothyroxine)
Calcium can decrease the absorption of thyroid hormones. Administer calcium at least 4 hours apart.
Tetracyclines and Fluoroquinolones (antibiotics)
Calcium can chelate these antibiotics, reducing their absorption. Administer calcium at least 2-3 hours before or 4-6 hours after these antibiotics.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose (hypercalcemia) may include nausea, vomiting, constipation, thirst, polyuria, abdominal pain, muscle weakness, fatigue, confusion, and in severe cases, cardiac arrhythmias. Management involves discontinuing the supplement, rehydration, and monitoring serum calcium levels and renal function. In severe cases, intravenous fluids and diuretics may be necessary.
Pregnancy & Lactation
This supplement is generally considered safe and often recommended during pregnancy and lactation to meet increased calcium and vitamin D requirements. However, always consult with a healthcare provider to determine the appropriate dosage and ensure safety.
Side Effects
Contraindications
- Hypersensitivity to calcium carbonate, Vitamin D3, or any component of the formulation
- Hypercalcemia (abnormally high levels of calcium in the blood)
- Hypercalciuria (abnormally high levels of calcium in the urine)
- Severe renal impairment or kidney stones (nephrolithiasis)
- Vitamin D toxicity
Drug Interactions
Digoxin
High calcium levels can increase the risk of digoxin toxicity. Monitor carefully if co-administered.
Bisphosphonates
Calcium can interfere with the absorption of bisphosphonates. Administer calcium at least 30-60 minutes after bisphosphonates.
Thiazide diuretics
May increase the risk of hypercalcemia by reducing urinary calcium excretion.
Thyroid hormones (e.g., levothyroxine)
Calcium can decrease the absorption of thyroid hormones. Administer calcium at least 4 hours apart.
Tetracyclines and Fluoroquinolones (antibiotics)
Calcium can chelate these antibiotics, reducing their absorption. Administer calcium at least 2-3 hours before or 4-6 hours after these antibiotics.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose (hypercalcemia) may include nausea, vomiting, constipation, thirst, polyuria, abdominal pain, muscle weakness, fatigue, confusion, and in severe cases, cardiac arrhythmias. Management involves discontinuing the supplement, rehydration, and monitoring serum calcium levels and renal function. In severe cases, intravenous fluids and diuretics may be necessary.
Pregnancy & Lactation
This supplement is generally considered safe and often recommended during pregnancy and lactation to meet increased calcium and vitamin D requirements. However, always consult with a healthcare provider to determine the appropriate dosage and ensure safety.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date, depending on the manufacturer.
Availability
Pharmacies, drugstores
Approval Status
Approved
Patent Status
Generic
Clinical Trials
Numerous clinical trials and studies have demonstrated the efficacy of calcium and vitamin D supplementation in preventing and treating osteoporosis, reducing fracture risk, and maintaining bone mineral density.
Lab Monitoring
- Serum calcium levels (especially for long-term use or in patients with renal impairment)
- Serum 25-hydroxyvitamin D levels
- Renal function (creatinine, GFR) in patients with renal impairment or long-term use
- Urine calcium excretion (in patients with a history of kidney stones)
Doctor Notes
- Emphasize the importance of adequate dietary calcium and vitamin D intake alongside supplementation.
- Advise patients on lifestyle modifications for bone health, including regular weight-bearing exercise and avoiding smoking.
- Monitor serum calcium, vitamin D levels, and renal function periodically, especially in patients at risk of hypercalcemia or renal impairment.
- Counsel patients on potential drug interactions, particularly with antibiotics and thyroid hormones.
Patient Guidelines
- Take the tablet exactly as prescribed by your doctor or as directed on the label.
- Do not exceed the recommended dose without consulting a healthcare professional.
- It is generally recommended to take this supplement with food to improve absorption and reduce stomach upset.
- Ensure adequate fluid intake to help prevent kidney stone formation.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Ostogen-D Forte is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Engage in regular weight-bearing exercise to support bone health.
- Maintain a balanced diet rich in calcium (dairy products, leafy greens) and Vitamin D (fatty fish, fortified foods).
- Moderate sun exposure can help the body produce Vitamin D; however, protect your skin from excessive sun.
- Avoid smoking and excessive alcohol consumption, as these can negatively impact bone density.
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